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《Chinese Journal of Difficult and Complicated Cases》 2017-03
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Effect of Shensongyangxin capsule on recurrence after radiofrequency ablation for patients with atrial fibrillation

ZHUO Chaogui;WANG Shun;ZHANG Kai;HU Shan;YANG Yousheng;WU Gang;Third Department of Internal Medicine,Anlu Puai Hospital;  
Objective To observe the effects of Sheruongyangxin capsule on recurrence after radiofrequency ablation in patients with atrial fibrillation(AF).Methods 80 patients with AF treated with radiofrequency ablation in Renmin Hospital of Wuhan University from February 2014 to October 2015 as research objects were enrolled and then randomly allocated to control group(conventional treatment) and observation group(conventional treatment plus Sheruongyangxin capsule).Blood biochemistry test,24 h Holler monitoring and echocardiography were examined in all patients before and 6 months after ablation,then recording N terminal pro brain natriuretic peptide(NT-proBNP),left atrial diameter(LAD),left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD),left ventricular ejection fraction(LVEF),early diastolic mitral flow velocity and diastolic mitral flow velocity ratio(E/A) and post ablation recurrence.Results Compared with pre-ablation,NT-proBNP was decreased in both groups after ablation[control group:(474.0 ± 122.4) ng/L vs.(363.53 ±117.91) ng/L,observation group:(466.6 ± 125.1) ng/L vs.(263.58 ±84.35) ng/L],and observation group was lower than control group(P 0.01).LAD was also decreased in both groups after ablation[control group:(37.71 ±2.89)mm vs.(33.59 ±2.04)mm,observation group:(38.27 ±3.05)mm vs.(32.35 ±1.77)mm],and observation group was lower than control(P =0.005).LVEDD was decreased in both groups after ablation[control group:(56.18±3.07) mmvs.(48.04 ±1.08) mm,observation group:(55.72 ±3.14) mmvs.(44.60 ±1.57) mm],and observation group was lower than control group(P =0.004).LVESD was decreased in both groups after ablation[control group:(32.56 ± 1.30) mm vs.(28.96±1.05) mm,observation group:(32.36±1.27) mmvs.(26.50 ± 1.23) mm],observation group was lower than control group(P =0.005).LVEF was increased in both groups after ablation[control group:(59.6 ±4.6)%vs.(63.0 ±3.9)%,observation group:(58.6 ± 4.8)%vs.(64.7 ± 4.3)%],observation group was higher than control group(P = 0.004).E/A was also increased in both groups after ablation[control group:(0.92 ±0.16) vs.(1.27 ±0.13),observation group;(0.92 ±0.12) vs.(1.53 ±0.08)],observation group was higher than control group(P =0.005).Postablation recurrence was recorded in 11 cases(27.50%) in control group and 4 cases in observation group(10.00%).There were statistical significance in recurrence rate between the two groups(P = 0.045).Conclusion Shensongyangxin capsule could effectively reduce AF recurrence after radiofrequency ablation,meanwhile,lowering NT-proBNP and LAD 6 months after ablation.
【Fund】: 国家自然科学基金资助项目(81270305 81670363)
【CateGory Index】: R541.75
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