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《Chinese Journal of Difficult and Complicated Cases》 2017-04
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Efficacy and prognosis of recombinant human brain natriuretic peptide in elderly patients with acute decompensated heart failure

ZHANG Huiying;HAO Yanli;LI Yanhui;HUANG Ying;Department of Internal Medicine,Liaoning Jinqiu Hospital;  
Objective To investigate the efficacy and prognosis of recombinant human brain natriuretic peptide in elderly patients with acute decompensated heart failure.Methods Ninety-two cases of elderly patients with acute decompensated heart failure were selected,they were treated in hospital from February 2015 to February 2016,and they were divided into the observation group(46 cases) and control group(46 cases).The patients of two groups were all treated with standard practice for anti-heart failure,include maintaining the smooth flow of the respiratory system,oxygen,low sodium salt diet,correct electrolyte imbalance,and given ACEI,diuretic,cardiac,vasodilators and inotropic drugs.The patients of control group were treated with nitroglycerin(dissolved in 5%sodium chloride solution for intravenous infusion,the initial dose of the first day were 10 μg/rain,increase 5 μg/min in every 5min until 40 μg/min,and keep 5 mg/d continuous intravenous infusion for 4d),and on the basis of the control group,the patients of observation group were treated with recombinant human brain natriuretic peptide(the initial dose was 1.5 μg/kg for intravenous pulse shock treatment,then keep 0.007 5 μg·kg~(-1) · min~(-1)) continuous intravenous infusion for 24 h,and keep 0.5 mg/d(0.007 5 μg · kg~(-1) · min~(-1)) intermittent treatment for 4d.The patients of two groups were all treated for 6 months in a row.The clinical effect,safety evaluation and changes of the levels of LVESD,LVEDD,LVEF,CRP,BNP,24 h urine output of two groups were compared.Results After the appropriate treatment,the patients of the observation group got a total effective rate of 95.7%,which was significantly better than the 82.6%of the control group(x~2 =4.039,P =0.044);The levels of LVESD,LVEDD,CRP,BNP of the observation group were significantly lower than those of the control group(t =2.739,t =2.253,t =3.897,t =5.162,P =0.004,P =0.013,P = 0.002,P =0.000);The levels of LVEF,24 h urine output of the observation group were significantly higher than those of the control group(t =9.722,P =0.000);There were headache,abdominal pain,orthostatic hypotension,elevated serum potassium,elevated transaminase and other adverse reactions occurred in both two groups,but there were no statistically significant between the two groups(x~2 =0.177,x~2 =2.222,x~2 =0.956,X~2 =0.474,x2 = 1.593,P =0.674,P =0.136,P =0.328,P = 0.491,P = 0.207).Conclusion With treating elderly patients with acute decompensated heart failure,recombinant human brain natriuretic peptide can obtain the exact effect,effectively relieve the clinical symptoms,improve the ventricular remodeling,improve the heart function,and it is safe,reliable and conducive to the prognosis of patients.
【CateGory Index】: R541.6
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 WANG Lin;CHEN Lixue;XIA Xuhui;WAN Shuping;Department of Cardiology,Tianmen First People's Hospital;;The effect of rhBNP on chronic heart failure with diuretic resistance[J];疑难病杂志;2015-12
2 DAI Pei-sheng;HAN Ya-yan;CUI Juan-min;WANG Yan;LI Xue-qi;Department of Cardiology,Shuangyashan Coal General Hospital;Department of Cardiology,the Fourth Hospital of Harbin Medical University;;Observation on Clinical Efficacy of Recombinant Human Brain Natriuretic Peptide in Treatment of Decompensated Acute Attack of Chronic Heart Failure[J];医学综述;2014-04
3 LUO Yuan-yuan,LIN Xin-feng.Department of ICU,the First Affiliated Hospital of Guangzhou University of Traditional China Medicine,Guangzhou 510405,China;Effects of recombinant human brain natriuretic peptide on the heart rate variability in patients with heart failure[J];实用医学杂志;2013-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Li Kui;The Second People's Hospital of Yibin;;Analysis of the Human Recombinant B-type Natriuretic Peptide in Patients with Chronic Heart Failure Clinical Curative Effect of Acute Decompensated Period[J];四川医学;2015-10
2 SHI Xia;MIAO Fei;WU Hong-chao;Department of Cardiovascular Medicine,Shenzhen City the Third People’s Hospital;;Clinical observation of recombinant human brain natriuretic peptide for dilated cardiomyopathy chronic heart failure acute exacerbation patients with poor effect by sodium nitroprusside[J];中国实用医药;2015-28
3 ZHANG Xiao-Fang;Respiratory Department,The Xinjin People's Hospital;;The improvement of acute exacerbation of chronic obstructive pulmonary disease concomitant with chronic heart failure by recombinant human brain natriuretic peptide[J];实用医院临床杂志;2015-05
4 WANG Hui-yuan;People's Hospital of Wenshui;;Clinical effectiveness analysis of rhBNP for the treatment of patients with heart failure[J];中国实用医刊;2015-11
5 WANG Ya-yun;CHEN Man-hua;Department of Cardiology,Central Hospital of Wuhan;;Effect of recombinant human brain natriuretic peptide on noninvasive hemodynamic parameters of elderly patients with refractory heart failure[J];实用药物与临床;2015-04
6 LI Li;LU Zhi-qiang;WEI Man-man;Department of Cardiology,Henan Provincial Chest Hospital;;Clinical observation of refractory heart failure of 39 patients treated by recombinant human brain natriuretic peptide[J];医药论坛杂志;2015-01
7 LIN Hui;CHEN Xiaohuan;WU Zhihua;ZHANG Donghui;CHEN Xiaoyan;Department of Function, Fourth People's Hospital of Shenzhen;Department of Endocrinology, Fourth People's Hospital of Shenzhen;Department of Cardiology, Fourth People's Hospital of Shenzhen;Department of Clinical Laboratory, Fourth People's Hospital of Shenzhen;;Association of pro-B-type natriuretic peptide levels with heart rate variability in diabetic patients[J];南方医科大学学报;2015-01
8 Jiang Zhongjun;Fei Xinxiong;Wang Yu;Central Hospital of Huangshi City;;Application of ICG noninvasive cardiac output measurement for patients with chronic phase of acute decompensated heart failure[J];护理研究;2014-33
9 LIU Rui-lian;Physical Culture Institute of Yichun University;;Effect of HRV on Exercise Preventing and Curing Senile Cardiovascular Disease[J];宜春学院学报;2014-03
10 MA Lan;JIN Zhen-yi;JIN Yi-wu;CHEN Ping;Department of Cardiology,Affiliated Hospital of Yanbian University;;The Impact of Levosimendan on Heart Rate Variability in Patients With Acute De-compensated Heart Failure[J];中国循环杂志;2014-03
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 TONG Sui-yang;XIA Hao;WANG Xin;Li Lei;Department of Cardiology,Renmin Hospital of Wuhan University;;A Study of Clinical Efficacy and Safety of Recombinant Human Brain Natriuretic Peptide in Elderly Patients with Acute Heart Failure Caused by Acute Myocardial Infarction[J];临床误诊误治;2015-08
2 LI Aihua TANG Liangqiu ZHANG Shebing Department of Cardiology,Yuebei People's Hospital,Guangdong Province,Shaoguan 512026,China;Comparison of efficacy between lyophilized recombinant human brain natriuretic peptide and milrinone for the treatment of congestive heart failure[J];中国现代医生;2012-21
3 SUN Jia-ying1,HUO Hai-yang2,ZHU Li-dong3,SUN Jin-min4(1.Respiratory Department,The Fourth Affiliated Hospital of China Medical University,Shenyang 110032,China;2.Cardiovascular Department,The First Hospital of China Medical University,Shenyang 110001,China;3 Cardiovascular Department,Benxi Central Hospital,Benxi 117000,China;4.China Medical University,Shenyang 110001,China);Clinical efficacy of lyophilized recombinant human natriuretic peptide on acute decompensated heart failure[J];实用药物与临床;2012-06
4 ZHANG Wei1,MA Xiao-chuan1,GAO Zhi-yao1,WANG Fang2,ZHANG Tao1(1.Department of Cardiology,Affilitated Hospital of Yan'an University,Yan'an,China 716000;2.Department of Cardiology,Center Hospital of Hanzhong,Shanxi,China 723000);Assessment of Rho-kinase inhibitor in heart failure with preserved left ventricular ejection fraction patients[J];实用药物与临床;2011-05
5 ZHANG Bing-rong(Department of Pharmacy,The Third People's Hospital of Tianshui,Tianshui 741000,China);Clinical progress of tolvaputan in treating heart failure[J];实用药物与临床;2011-02
6 LONG Shuangqi,LIU Bin,ZOU Guihe,CHEN Yuhong Department of Cardiology,The People's Hospital(New Hospital) in Yongzhou City of Hu'nan Province,Yongzhou 425000,China;The Clinical observation of recombinant human brain natriuretic peptide to treat acute myocardial infarction with heart failure[J];中国医药导报;2011-08
7 LI Wen-ming,CHEN Dong-dong,XIE Wen-tiao,et al.Anxi County Hospital,Anxi Fujian 362400,China;Efficacy of recombinant human brain natriuretic peptide in treatment of patients with acute left heart failure[J];临床和实验医学杂志;2010-15
8 LUO Yuan-yuan , SUN Shao-xi, LI Heng ,et al (Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515,China );Effects of Recombinant Human Brain Natriuretic Peptide versus Sodium Nitroprusside for the Treatment of Acute Decompensated Heart Failure[J];医学临床研究;2010-02
9 FU Yao,YANG Guang,BAI Xiao-juan,JIA Da-lin,MA Yu-long,QI Guo-xian (Department of Cardiology,The First Affiliated Hospital,China Mdical University,Shenyang 110001,China);Efficacy of recombinant human brain natriuretic peptide in congestive heart failure[J];中国医科大学学报;2006-02
10 GU Dong feng *, HUANG Guang yong, HE Jiang, et al *Department of Population Genetics and Prevention, Fu Wai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100037, China;Investigation of prevalence and distributing feature of chronic heart failure in Chinese adult population[J];中华心血管病杂志;2003-01
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