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《Chinese Journal of Difficult and Complicated Cases》 2017-04
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Effects of urapidil on heart function and NT-proBNP in treatment of patients with hypertension and acute heart failure

GAO Tianlin;REN Hui;WANG Jiawen;WANG Rui;Internal Medicine-Cardiovascular Department,Ankang Central Hospital of Shaanxi;  
Objective Investigate the effects of urapidil on heart function and NT-proBNP in treatment of patients with hypertension and acute heart failure.Methods 92 cases ofpatients with hypertension and acute heart failure were selected,which were treated in hospital from March 2014 to March 2016,and were divided into the observation group(46cases)and control group(46 cases).The patients of two groups were all treated with routine comprehensive treatment,including the maintenance of airway,aerosol inhalation oxygen,diuretics,cardiac,anti-infection,asthma,phlegm and so on.The patients of control group were treated with nitroglycerin(10 mg dissolved in 50 ml 0.9%Naclsolution,intravenous infusion,infusion of 5-10 μg/min within 6h,the maximum dose ≤20 μg/min),while the patients of observation group were treated with urapidil hydrochloride injection(100 mg dissolved in 50 ml 0.9% NaCl solution,intravenous infusion,infusion of 50-100μg/min within 6h,the maximum dose of ≤300 μg/min).The patients in both two groups were given continuous administration for 48 hours,the drug concentration was adjusted according to the patients' blood pressure and cardiac function,and the course of treatment was seven days.Compare the clinical effects,cardiac function,blood pressure,NT-proBNP,incidence of side effects,adverse eventsat 3-month follow-up of two groups.Results After the appropriate treatment,the patients of the observation group got a total effective rate of 95.7%,which was significantly better than the 82.6% of the control group(x~2 =4.039,P =0.044);The levels of heart rate,NT-proBNP,SBP,DBP of the observation group were significantly lower than those of the control group(t =1.762,8.660,6.225,1.941,P =0.041,0.000,0.000,0.028);The levels of LVEF,CI of the observation group were significantly higher than those of the control group(t =1.781,4.164,P =0.039,0.000);But in the terms of LVEDV,LVESV,there was no significant difference before and after treatmentin both two groups(t =0.679,0.632,P =0.249,0.264);There were hypotension,palpitations,dizziness,tachycardia,gastrointestinal reactions,facial flushing,there were sudden cardiac death,cardiac function deterioration,non-fatal myocardial infarctionand other adverse reactions occurred in both two groups,and the incidence of adverse reactions in the observation group was significantly lower than that in the control group(P 0.05).Conclusion With treating patients with hypertension and acute heart failure,urapidil can obtain the exact effect,significantly improve the cardiac function,reduce the levels of NT-proBNP,and with a low incidence of adverse reactions.It is safe,effective and worthy of clinical promotion.
【CateGory Index】: R541.6;R544.1
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