Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Difficult and Complicated Cases》 2017-04
Add to Favorite Get Latest Update

Effect of trimebutine maleate in treatment of irritable bowel syndrome and its effect on inflammatory mediators

ZHI Jiaxi;SHI Hanyan;XU Xiaorong;WU Yahui;WU Chengming;Shanghai Tongji University School of Medicine;  
Objective To observe trimebutine maleate in treatment of irritable bowel syndrome(IBS) and its effect on inflammatory mediators.Methods Ninety-six patients with IBS were randomly divided into observation group and control group in Shanghai Tenth People's Hospital from March 2015 to March 2016.2 groups of patients during treatment were given adequate rest,a healthy diet,correct water and electrolyte disorders,maintaining acid-base balance and other conventional treatment.The control group were treated by compound diphenoxylate 2.5 mg,tid and pinaverium bromide 50 mg,tid;observation group of combined use of Trimebutine Maleate Tablets 50 mg based on the treatment in control group.Two groups of patients were treated for 4 weeks.The clinical efficacy,clinical symptom score,TNF-α,IL-10,IL-18 and the incidence of adverse reactions were compared between the 2 groups.Results After treatment,the total effective rate of observation group was 89.6%,significantly higher than the control group 70.8%(x~2 =5.315,P=0.021);stool,defecation,abdominal pain symptoms,TNF-α,IL-18 levels lower than the control group,IL-10 higher than that of the control group(t = 2.513,t =2.813,t =6.012,t =4.487,t =8.197,t =4.722,P 0.01);nausea,vomiting,dizziness,headache,drowsiness,dry mouth,fatigue and other adverse symptoms occurred during the treatment period,but the 2 groups were compared,there were no significant differences(P 0.05).Conclusion Effect of trimebutine in the treatment significantly improved the IBS exact,inflammatory reaction;effectively relieve the clinical symptoms,good safety,it is worthy of clinical application.
【CateGory Index】: R574
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved