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《Chinese Journal of Difficult and Complicated Cases》 2017-04
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Effects of hUC MSCs on serum factors,DAS28 and HAQ score in patients with rheumatoid arthritis

ZHANG Yuhong;ZHOU Jun;LUO Li;MENG Yan;JIANA·SHA Lijiang;Department of Nephropathy,Xinjiang Production and Construction Corps Hospital;  
Objective To observe the effect of human umbilical cord mesenchymal stem cells(hUC MSCs) on DAS28,HAQ score and serum factors in patients with rheumatoid arthritis(RA).Methods From January 2014 to March2016,in First Affiliated Hospital of Xinjiang Medical University,100 RA patients enrolled as the research object,they were divided into observation group(n = 55) and control group(n =45),the control group was given NSAIDs and DMARDs;observation group also were given treatment on the basis of hUC MSCs treatment,between the 2 groups,rheumatoid factor,anti CCP antibody,CRP and B cells and CD4~+Treg level,DAS28 score,HAQ score were compared.Results Before treatment,2 groups of rheumatoid factor,anti CCP and CRP had no significant difference(t =0.434,t =0.955,t =0.684,P 0.05);after treatment,observation of rheumatoid factor,CRP group were lower than before treatment(t = 6.789,t =16.183,P 0.05),the control group reduced rheumatoid factor(t =2.542,P 0.05).Rheumatoid factor and CRP in the observation group than the control group decreased significantly(t =-2.918,t =-14.147,P 0.05).Before the treatment,no statistical significance of B cells in the 2 groups and the difference of CD4~+ Treg(t =-0.461,t = 0.172,P 0.05);after treatment,the observation group CD4~+ Treg higher than that before treatment,while B cells decreased(t=-10.875,t =7.174,P 0.05),and the observation group was better than the control group(t = 9.751,t =-8.115,P 0.05).Before treatment,there was no significant difference in DAS28 and HAQ scores between the 2 groups(t =-0.097,t =-0.276,P 0.05).After treatment,the control group had no significant changes in DAS28 and HAQ scores(t=1.182,t=1.747,P 0.05).The DAS28 and HAQ scores in the observation group were lower than those before treatment(t =10.417,(=-5.905),and were better than those in the control group(t =-5.905,t =-5.650,P 0.05).Conclusion The hUC MSCs in the treatment of RA has a certain effect,can improve the patient s condition,adjust immune tolerance,it is worth further study.
【Fund】: 新疆维吾尔自治区自然科学基金(2014211C045)
【CateGory Index】: R593.22
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