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《Chinese Journal of Difficult and Complicated Cases》 2017-04
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Expression of NUMB and SIP1 in gastric carcinoma and its clinical significance

GU Hanbo;CAI Xiangjun;LI Yiming;LIU Hongtao;WANG Xiaohuan;Department of General Surgery,the 202 Hospital of PLA;  
Objective To investigate the relationship between the expression of cell fate determinants of membrane associated protein(NUMB protein) and Smad interacting protein 1(SIP1) in gastric cancer tissues and adjacent tissues.Methods Collected and screened from April 2012 to May 2015 in Chinese people's Liberation Army 202 nd Hospital Department of Pathology,surgical resection and clinical diagnosis of gastric cancer 50 cases,they was detected by immunohistochemical method in specimens of gastric cancer and adjacent tissues(tumor distance beyond 5 cm),expression of NUMB and SIPl protein content were detected,analysis of its correlation with clinical pathological factors.Results The expression of NUMB in gastric cancer tissue lower than that of adjacent tissues(8.00%vs.88.00%,x~2 =60.938,P 0.05),and the expression of SIPl was significandy higher than that of the adjacent tissues(86.00%vs.36.00%,x~2 = 24.212,P 0.05);the expression of NUMB in different gender,age,TNM stage,depth of invasion,tumor size,lymph node metastasis,tumor differentiation,Lauren classification of gastric cancer's difference were not statistically significant(P 0.05),the expression of SIPl protein in T3-4 gastric carcinoma was significantly higher than that of T1-2(x~2 = 3.476,P = 0.039),in gastric cancer,there was a negative correlation between the expression level of NUMB protein and SIPl protein(r =-0.306,P = 0.030).Conclusion The expression level of NUMB in gastric cancer was down regulated,while the expression level of SIP1 was upregulated,and the expression level of two was negatively correlated.NUMB may be a potential tumor suppressor gene,which can be used for early diagnosis of gastric cancer.SIP1 can promote the invasion of gastric cancer and can be used to monitor the progression of gastric cancer.
【CateGory Index】: R735.2
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