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《Chinese Journal of Difficult and Complicated Cases》 2017-04
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Effect of FAC regimen chemotherapy on oxidative stress in patients with advanced breast cancer

HUANG Jinghui;YOU Dongshan;CHEN Xin;ZHOU Yunna;CHEN Aimin;Department of Oncology,the First Peoples Hospital of Chuzhou;  
Objective To observe the effect of FAC(5 fluorouracil,cyclophosphamide,adriamycin) chemotherapy on the level of oxidative stress in patients with advanced breast cancer.Methods From May 2014 to May 201 S,68 patients with advanced breast cancer were treated in the Department of oncology,the first peoples Hospital of Chuzhou city.The patients were randomly divided into observation group and control group(n = 34).The control group was treated with TAC chemotherapy,the observation group was treated with FAC chemotherapy;2 groups of patients with continuous chemotherapy of 2]d for 1 cycles,compared the clinical efficacy of the 2 groups after 3 weeks of chemotherapy and nitric oxide(NO),malondialdehyde(MDA),glutathione peroxidase(GSH),superoxide dismutase(SOD),catalase(CAT),carcinoembryonic antigen(CEA) and ferritin(SF) level changes and adverse reactions.Results Recently,the total efficiency of observation group was significantly higher than the control group(82.4%vs.55.8%,X~2 =4.533,P =0.033).After chemotherapy,the levels of NO,MDA,GSH,SOD,CAT,CEA and SF in the 2 groups were significantly higher than those in the control group(t =5.648,t =5.187,t = 1.723,t =2.157,t = 1.848,t =4.553,P 0.05).During the period of chemotherapy in patients with adverse reactions of 2 groups were neutropenia,nausea/vomiting,leukopenia,thrombocytopenia,low hemoglobin,hair loss,fatigue,low albumin,liver function damage,joint and muscle pain and cardiac toxicity,there was no significant difference between the 2 groups(x~2 =0.197,X~2 = 1.619,X~2 =0.188,X~2 =0.197.X~2 =0.188,X~2 =0.188,X~2 =0.188,x~2 =0.924,x~2 =0.188,x~2 =0.706,X~2 =0.240,P 0.05).Conclusion Application of breast cancer patients with FAC regimen have curative effect,oxidative stress in the body is relatively light,and the adverse reactions could be tolerated,it can be used as one of the chemotherapy of patients with breast cancer.
【CateGory Index】: R737.9
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