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《Chinese Journal of Difficult and Complicated Cases》 2017-04
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Effect of Xiezhuojiedu decoction on TLR4,MD2,IL-13,NF-κB on ulcerative colitis model rats

LIU Jianping;YANG Qianyu;LANG Xiaomeng;ZHAO Yuan;YAO Cuicui;Department of Slpenogastric,Hebei Chinese Traditional Medicine Hospital;  
Objective To observe the effects of Xiezhuojiedu decoction on TLR4,MD2,IL-13 and NF-kB of ulcerative colitis(UC)rats.Methods Established the animal models of ulcerative colitis with TNBS/ethanol joint modeling method.After the irrigation treatment,the expression of TLR4,the content of MD2,IL-13 and NF-kB in serum were detected,respectively.Results Xiezhuojiedu decoction can decrease the expression of TLR4,MD2 and NF-kB,improve the level of IL-13.The comparison between the two groups showed statistical significance(F = 110.490,F =271.137,F = 10.723,F =92.297,P 0.05).Conclusion The effects of Xiezhuojiedu decoction on UC rats are remarkable,it may be related to decreasing the expression of TLR4,MD2,and NF-kB,improving the level of IL-13.
【Fund】: 河北省自然科学基金(H2014206462)
【CateGory Index】: R285.5
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