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《Chinese Journal of Difficult and Complicated Cases》 2017-04
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Protective effects of diammonium glycyrrhizinate on peritoneal dialysis rat model of peritoneal function

WEI Zhifeng;LU Jifang;LIU Shengjun;LI Sumin;WNAG Linlin;LIU Hua;Department of Nephrology,First Affiliated Hospital of Hebei North University;  
Objective To study the protective effects of diammonium glycyrrhizinate on the peritoneal function of peritoneal dialysis rats.Methods Forty male rats were randomly divided into five groups,namely control group,model group,saline group,pentoxifylline group,glycyrrhizin diamine group,10 rats in each group,continuous experiment for 4 weeks,the peritoneal function in rats after 4 weeks(ultrafiltration,Durea/Purea) and related indexes(blood urea nitrogen creatinine clearance rate,TNF-α,and MCP-1) were tested.Results The amount of ultrafiltration,D4/D0 of model group compared with pentoxifylline group and glycyrrhizin diamine group reduced significantly,Durea/Purea increased significantly(F =8.935,7.824,9.361,P 0.05),pentoxifylline group's ultrafiltration volume increased significantly than in the glycyrrhizinate diamine group,while Durea/Purea,D4/D0 were more lower,but the difference were not significant(F =7.363,8.923,P 0.05).Model group's urea nitrogen,creatinine clearance rate reduced significantly than pentoxifylline group and glycyrrhizin diamine group,Durea/Purea increased more significantly(F =7.824,7.911,P 0.05),pentoxifylline group urea nitrogen and creatinine clearance rate decreased more significantly compared to glycyrrhizinate diamine group,but the difference were not significant(P 0.05);compared with the model group,TNF-α,MCP-1 increased significantly compared with pentoxifylline group and glycyrrhizin diamine group(P 0.05),cyclohexanone theobromine group's MCP-1 and TNF-α were lower than Glycyrrhizin acid group,the difference were not significant(P 0.05).Conclusion 4.25%glucose peritoneal dialysis solution enables impair rat peritoneal function,glycyrrhizin acid can reduce peritoneal injury,reduce deterioration of peritoneal function.
【CateGory Index】: R692.5;R-332
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