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《Chinese Journal of Difficult and Complicated Cases》 2017-05
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The expression and clinical significance of serum levels of galectin 3 and brain natriuretic peptide in patients with congestive heart failure

LI Dan;HUANG Jiwei;WANG Yu;YANG Peng;Department of Cardiology,Zigong First People's Hospital,Sichuan Province;  
Objective To investigate the expression of serum galectin 3 and brain natriuretic peptide(BNP) and its diagnostic and prognostic value in heart failure.Methods Eighty six patients with heart failure treated in department of cardiology of Zigong First People's Hospital from January 2016 to October 2016 in Sichuan were selected as observation group,NYHA cardiac function grade Ⅱ to Ⅳ class,of which 28 cases of grade Ⅱ,grade Ⅲ in 26 cases,grade Ⅳ in 32 cases;also chose 42 cases of volunteers underwent health examination in our hospital as control group.The levels of galectin 3 and BNP in the two groups were measured and the diagnostic value of galectin 3 and BNP in the diagnosis and prognosis of heart failure was analyzed by echocardiography.Patients were followed up for 10 months after discharge and the heart events were observed.Results The levels of galectin 3,BNP and LVEDD in the observation group were higher than those in the control group(t/P =23.494/0.000,t/P =45.741/0.000,t/P =9.296/0.000) and the LVEF value was lower than that in the control group(t/P = 11.819/0.000).The higher the cardiac function level,the higher the corresponding level of galectin 3,BNP levels and LVEDD values,whereas the LVEF values were decreased.The levels of serum galectin 3 and BNP in patients with cardiac events were significantly higher than those without heart events(t/P = 22.655/0.000,t/P =29.301/0.000).Serum galectin 3 was more sensitive to heart failure diagnosis(95.8%vs.76.9%),and BNP was more specific in patients with heart failure(99.0%vs.62.4%).The difference was statistically significant(P 0.05).Conclusion The higher the level of serum galectin 3 and BNP,the lower the level of LVEF,which is of great clinical significance in the diagnosis and prognosis of patients with heart failure.
【CateGory Index】: R541.6
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【Citations】
Chinese Journal Full-text Database 8 Hits
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【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 TENG Mingzi;WANG Xiaoyan;Dept. of Cardiology,Wuxi Third People's Hospital;;Clinical Observation of Xinmailong Injection Combined with Trimetazidine in the Treatment of Chronic Heart Failure of Coronary Heart Disease (Qi Yang-deficiency)[J];中国药房;2017-26
2 LI Xinli;ZHENG Xuhui;Department of Cardiology,the First Affiliated Hospital of Nanjing Medical University;;Heart failure biomarkers:the current status in China[J];临床心血管病杂志;2017-09
3 ZONG Bin;Department of Cardiology, Xuzhou Central Hospital Jiangsu Province;;Clinical value analysis of peripheral blood sST2 on risk stratification and prognosis in patients with AHF[J];中国医药导报;2017-26
4 WU Zengfan;CHEN Weiwei;LIU Xianxia;Internal Medicine-Cardiovascular Department,The Second Affiliated Hospital of Hainan Medical University;;Effect of Xinmailong Injection on Heart Failure of Coronary Heart Disease Patients' Serum BNP,hsCRP and VEGF[J];中华中医药学刊;2017-09
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【Secondary Citations】
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