Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Difficult and Complicated Cases》 2017-05
Add to Favorite Get Latest Update

Effect of dual antiplatelet therapy after intravenous thrombolysis in patients with mild ischemic stroke

LI Hong;CHEN Na;LU Liansheng;LU Haili;LI Jing;WANG Congjie;ZHENG Li;ZHANG Bin;SONG Qiao;SHI Wanying;Department of Neurology,Shijiazhuang First Hospital;  
Objective To observe the therapeutic effect of intravenous thrombolysis on mild ischemic stroke and the safety of dual antiplatelet therapy after intravenous thrombolysis.Methods 114 patients with mild ischemic stroke who were treated in Department of Neurology,First Hospital of Shijiazhuang City from December,2012 to December,2015 were divided into 2 groups according to different treatment methods.The control group was treated with aspirin after intravenous thromblysis.The patients in treatment group were treated with intravenous thrombolysis on the basis of aspirin therapy.After 3 months,the curative effect of the patients,functional score and inflammatory factors was compared.The hemorrhage rate,mortality and recurrence rate were analyzed.Results The total effective rate of the observation group was 96.6%,which higher than that of the control group(75.0%)(P 0.05).After treatment,the NIHSS and mRS scores in the observation group were lower than those in the control group,while BI increased(P 0.05).After treatment,the levels of hs-CRP and IL-6 in the 2groups were lower than those before treatment,and the observation group was lower than the control group(P 0.05).The recovery rate of inflammatory factors in the observation group was higher than that in the control group(P 0.05).2 groups of patients with no cerebral hemorrhage and mortality,but the control group recurrence rate was significantly higher than the treatment group(8.93%vs.3.45%,x~2=5.543,P =0.019).Conclusion Intravenous thrombolysis can improve the therapeutic effect and reduce the recurrence rate in patients with mild ischemic stroke.The dual antiplatelet therapy after intravenous thrombolysis will not increase the treatment risk.
【Fund】: 河北省卫计委2015年度医学科学研究重点课题计划项目(20150919)
【CateGory Index】: R743.3
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 5 Hits
1 ZHAO Wei;Department of Neurology, Heart Hospital for Taiwanese of Dongguan;;Risk Factors of Intravenous Thrombolysis-induced Hemorrhagic Transformation in Acute Ischemic Stroke Patients Complicated with Atrial Fibrillation[J];实用心脑肺血管病杂志;2015-12
2 ZHU Hai-bao;LI Yong;ZHANG Guan-wen;SHEN Yong-ling;DU Hai-song;Department of Neurology,Chengde Central Hospital;;Dual antiplatelet treatment after intravenous thrombolysis for mild ischaemic stroke[J];临床荟萃;2014-12
3 WANG Huan;LI Wei;LIU Cheng-Chun;WU Ya;YI Xu;ZHANG Zhi-Hong;LI Xiao-Shu;ZHANG Meng;Neurology Intensive Care Unit, Department of Neurology, The Third Affiliated Hospital of Third Military Medical University;;Assessing the Safety of Selectively Early Administration of Dual Antiplatelet Therapy in Patients with Cerebral Infarction after Intravenous Thrombolysis[J];中国卒中杂志;2014-10
4 Ke Laishun;Dong Mintian;Lu Wusheng;Department of Neurology,No.175,Hospital of the People’s Libration Army (Dongnan Hospital Affiliated to Xiamen University);;An efficacy study of intravenous thrombolytic therapy in 56 patients with cardiogenic cerebral embolism[J];卒中与神经疾病;2014-02
5 Huang Yinhui;Li Mingmei;Lin Youyu;Yang Meili;Xu Yingying;Zuo Shitu;Chen Zhenjie;Li Juanjing;Zhang Biyue;Cai Ruowei;Department of Neurology,Jinjiang Hospital;Department of Neurology,Anxi Mingxuan Hospital;Department of Neurology,Second Affiliated Hospital,Fujian Medical University;Department of Neurology,Affiliated First Hospital of Quanzhou,Fujian Medical University;;Efficacy and safety of antiplatelet therapy prior to intravenous thrombolysis in acute ischemic stroke patients[J];第三军医大学学报;2014-03
【Co-citations】
Chinese Journal Full-text Database 8 Hits
1 Yang Letian;Yan Fuling;Medical School of Southeast University;Department of Neurology,Zhongda Hospital Southeast University;;Reocclusion after reperfusion therapy in patients with acute ischemic stroke[J];国际脑血管病杂志;2017-03
2 YANG Run-hua;FAN Yun-zhi;ZHANG Long-hai;Intensive Care Unit of Traditional Chinese Medicine Hospital of Nanjing;;Influencing Factors of Intravenous Thrombolysis- induced Hemorrhagic Transformation in Patients with Acute Cerebral Infraction[J];实用心脑肺血管病杂志;2015-12
3 Wang Bo;Zeng Tao;Liu Min;Sichuan Mianyang404 Hospital,the Affiliated Second Hospital of North Sichuan Medical University;;Comparison of clinical curative effect of intravenous thrombolysis and anticoagulation therapy in the treatment of patients with cardiogenic cerebral embolism[J];中国实用神经疾病杂志;2015-14
4 XIAN Wen-chuan;ZHU Yu-chang;SUN Chao-wen;ZHONG Wang-Tao;Department of Neurology,Affiliated Hospital of Guangdong Medical College;;Clinical observation on urokinase thrombolysis for stroke patients with non valvular atrial fibrillation[J];广东医学院学报;2015-02
5 WANG Si-nian;HUANG Zhi-mei;GONG Zi-li;Department of Neurology,the First People' s Hospital of Xinbei District of Chongqing;;Predictive Value of Plasma Big Endothelin-1,D-dimer Levels and Serum Lipoprotein(a) Level on Acute Ischemic Stroke[J];实用心脑肺血管病杂志;2015-04
6 LIN Peijian;ZHOU Weikun;LI Fuxiang;FAN Kaiwei;LI Gancheng;Cerebrovascular Disease Ward, Zhaoqing First People's Hospital;;Effects Comparison of Intravenous Thrombolysis, Simple Arterial Thrombolysis and Mechanical Auxiliary Arterial Thrombolysis for the Treatment of Cardiogenic Brain Embolism[J];临床医学工程;2015-03
7 ZHAO Yuping;Ciqu Health Institute of Tongzhou Distrct;;Influence of Premorbid Application of Antiplatelet Drugs on Severity and Prognosis of Ischemic Stroke[J];贵阳医学院学报;2015-02
8 Cao Honggui;The Neurological Rehabilitation Center,the Boai Convalescent Hospital;;Effects of transcranial ultrasound combined with thrombolytic therapy on the recanalization of patients with acute ischemic stroke[J];中国实用神经疾病杂志;2015-01
【Secondary Citations】
Chinese Journal Full-text Database 7 Hits
1 LOU Yi-ping;YAN Shen-qiang;ZHANG Sheng;CHEN Zhi-cai;WAN Jin-ping;LOU Min;Department of Neurology,Second Affiliated Hospital,Zhejiang University School of Medicine;;Impact of atrial fibrillation on clinical outcome in patients with acute ischemic stroke undergoing thrombolytic therapy[J];浙江大学学报(医学版);2014-01
2 XU Jing;WEI Xiu-e;RONG Liang-qun;Department of Neurology,General Hospital of Xuzhou Mine Group;;Risk Factors of Progressive Ischemic Stroke Based on Stroke Registry: A Prospective Study[J];实用心脑肺血管病杂志;2013-12
3 YOU Shou-jiang;CAO Yong-jun;XIAO Guo-dong;HAN Qiao;ZHANG Chun-yuan;WANG Wan-hua;KONG Yan;ZHANG Xia;LU Tao-sheng;HUANG Zhi-chao;LIU Chun-feng;Department of Neurology,Second Affiliated Hospital of Soochow University;;The therapeutic effect and prognosis of acute cerebral infarction patients with atrial fibrillation treated by intravenous thrombolysis with recombinant tissue plasminogen activator[J];中华神经科杂志;2013-10
4 Ouyang Wanjiong;Huang Yinhui;Li Mingmei;Zhuo Shitu;Chen Zhenjie;Li Juanjing;Zhang Biyue;Ye Lichao;Cai Ruowei;Department of Neurology,Second Affiliated Hospital,Fujian Medical University;Department of Neurology,No. 180 Hospital of PLA;Department of Neurology,Mingxuan Hospital of Anxi County;;Efficacy of statins therapy prior to acute ischemic stroke on intravenous thrombolysis:report of 181 cases[J];第三军医大学学报;2013-18
5 LIN Yue-han,LOU Min,ZHU Ren-yang,YAN Yu-qing,CHEN Zhi-cai,Ding Mei-ping(Department of Neurology,The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China);Multi-mode MRI-based intravenous thrombolysis with recombinant tissue plasminogen activator(rtPA) reduces hemorrhagic transformation in ischemic stroke patients[J];浙江大学学报(医学版);2012-06
6 JI Hai-chao, YAN Fu-ling. Departmemt of Neurology, Zhongda Hospital, Affiliated to Southeast University, Nanjing 210009, China;Thrombolysis for mild stroke[J];中华脑血管病杂志(电子版);2012-05
7 SU Min~*,YANG Wei-xin,WANG Wan-hua,CAO Yong-jun,LU Tao-sheng,JIANG Xuan-fei,KONG Yan,LIU Chun-feng.* Department of Rehabilitation,First Affiliated Hospital of Soochow University,Suzhou 215006, China;Risk factors and prognosis for hemorrhagic transformation caused by intravenous thrombolysis treatment with recombinant tissue plasminogen activator treatment in acute cerebral infarction[J];中华神经科杂志;2011-11
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved