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《Chinese Journal of Difficult and Complicated Cases》 2017-05
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The effect of ezetimibe on three serum adipokine in patients with acute cerebral infarction

GUO Dianxuan;LI Xia;WANG Yun;ZHOU Hualan;Department of Geriatrics;Huai'an Hospital Affiliated to Xuzhou Medical University;  
Objective To estimate the effect of ezetimibe on three serum adipokine(chemerin,vaspin and apelin)in obese patients with acute cerebral infarction(ACI).Methods One hundred and fifty patients with ACI were enrolled in this study and they were divided into two group equally and randomly:control group(n = 75) and ezetimibe group(n =75).The levels of three adipokine(chemerin,vaspin and apelin) and three neurological score(FMA,NIHSS and Barthel)were measured in two points(before treatment and 4 weeks after treatment).Results Compared with before treatment,4weeks later,the levels of chemerin[(57.6 ±6.2) mg/L vs.(25.3 ±4.2)mg/L,t=37.35,P 0.01]and apelin[(177.3 ±22.6)ng/ml vs.(92.3 ± 16.1) ng/ml,t =26.53,P 0.01]were significantly reduced in ezetimibe group(P 0.05),while levels of vaspin[(6.4 ±0.8) ng/ml vs.(11.6 ± 1.1) ng/ml,t =33.11,P 0.01]were elevated.Only chemerin[(59.0±5.6) mg/L vs.(43.3±4.3)mg/L,t=19.26,P 0.01]and vaspin[(6.2±1.2) ng/ml vs.(7.4±0.7) ng/ml,t =7.481,P 0.01]could be found fluctuation after treatment in control group.Compared with control group,4 weeks after treatment,the levels of chemerin[(25.3 ±4.2)mg/L vs.(43.3 ±4.3)mg/L,t =13.95,P 0.01]and apelin[(92.3 ± 16.1)ng/ml vs.(175.8 ±21.2) ng/ml,t = 26.53,P 0.01]were significantly reduced in ezetimibe group,while levels of vaspin[(92.3 ± 16.l)ng/ml vs.(175.8 ±21.2) ng/ml,(=27.16,P 0.01]were elevated in ezetimibe group.Compared with control group 4 weeks after treatment,the level of neurological score(FMA and Barthel) in ezetimibe group were significantly elevated,NIHSS score reduced.Correlation analysis showed that after treatment with ezetimibe the levels of neurological score were negatively associated with chemerin(r =0.635,P 0.05) and apelin(r =0.652,P 0.05),while positively related with vaspin(r =0.606,P 0.05).Conclusion Early administration of ezetimibe may regulate ACI related adiponkine(chemerin,vaspin and apelin) and improve neurological recovery in ACI obesity patients.
【CateGory Index】: R743.33
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