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《Chinese Journal of Difficult and Complicated Cases》 2017-05
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The effects of 1,25-dihydroxyvitamin D_3 on the immunologic mechanism of IL-23/IL-17 in the experimental colitis

ZHAO Hongwei;LANG Xiaomeng;ZHU Yeshan;LIU Jianping;Department of Gastroenterology,Hebei General Hospital;  
Objective To investigate the effects of 1,25(OH)_2D_3 on the immunologic mechanism of IL-23/IL-17 in chronic colitis mice.Methods Thirty of mice were randomly grouped as follows;1,25(OH)_2D_3 group,model group,control group.Chronic colitis model was established,general condition and colon pathological changes were observed.The expressions of TNF-a and TGF-β proteins were detected by immunohistochemistry,and the expressions of IL-17,IL-23 proteins were detected by western blot.Results During the experiment,general condition and colon pathological were changed in the 1,25(OH)_2D_3 group compared with that of the model group,infiltration into the mucosa superficial layers of granulocytes,neutrophil infiltration of rectum were much severity in the model group by the microscope.However,mice in the 1,25(OH)_2D_3group,the colonic pathological section showed increased,neutrophils were significantly ameliorated;the results of immunohistochemical staining showed that the expressions of the TNF-a and TGF-β proteins in colonic tissues significantly decreased in the 1,25(OH)_2D_3 group compared with that of the model group(P 0.01),the results of western blot revealed that the proteins expressions of IL-17,IL-23 significantly decreased in the 1,25(OH)_2D_3 group compared with that of the model group(F = 1 447.52,P 0.01;F = 1 457.57,P 0.01).Conclusion The administration of 1,25(OH)_2D_3 could relieve the damages of chronic colitis in mice,which may be adjusted the immunologic mechanism of IL-23/IL-17 in intestinal tissues.
【CateGory Index】: R574.62
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【References】
Chinese Journal Full-text Database 2 Hits
1 Si Haipeng;Zhu Changle;Qin Fei;Ye Bai;Department of Pathology,Affiliated Hospital of Nanjing University of TCM;Jiangsu Province Hospital on Integration of Chinese and Western Medicine;Department of Gastroenterology,Affiliated Hospital of Nanjing University of TCM;;Changes of IL-23 and TNF-α in Different Stages of Ulcerative Colitis Treated by Chinese Materia Medica Empirical Formula[J];世界中医药;2018-01
2 JIAO Fangzhou;ZHANG Haiyue;ZHANG Wenbin;GONG Zuojiong;Department of Infectious Diseases,Renmin Hospital of Wuhan University;;The relationship between 25 hydroxyvitamin D level and chronic hepatitis C:a Meta-analysis[J];疑难病杂志;2017-08
【Citations】
Chinese Journal Full-text Database 2 Hits
1 CHEN Qiangmei Zhejiang Province Tonglu Country MCH,Tonglu 311500,China;The Study of the Mechanism of Mesalazine Release Granules on Serum IL-6,TNF-α in Ulcerative Colitis Patients[J];中国现代医生;2011-36
2 NIU Wenyuan ZHANG Meixi ZHAO Qing YUAN Huiyun YANG Tanbao QIN Hairong Digestive System Department,Shanxi Children's Hospital,Taiyuan 030001,China;Serum IL-17 Level in Infant Infectious Diarrhea and Ulcerative Colitis[J];中国现代医生;2010-05
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 WANG Li;Department of Internal Medicine, Zaozhuang Mining Group Tengnan Hospital;;Clinical analysis of Yiyang decoction combined with probiotics and mesalazine in treating ulcerative colitis[J];中国现代医生;2018-03
2 ZHAO Hongwei;LANG Xiaomeng;ZHU Yeshan;LIU Jianping;Department of Gastroenterology,Hebei General Hospital;;The effects of 1,25-dihydroxyvitamin D_3 on the immunologic mechanism of IL-23/IL-17 in the experimental colitis[J];疑难病杂志;2017-05
3 WANG Ke-qiang;Jinxi County Hospital of Traditional Chinese Medicine;;Comparison of Clinical Efficacies of Azithromycin and Pefloxacin in Treating Patients with Acute Enteritis[J];抗感染药学;2016-02
4 ZHENG Han-han;JIANG Xue-liang;Postgraduate Training Base of Ji'nan Military District General Hospital of Liaoning Medical University;;Comparison of Clinical Effect of Mesalazine Suppositories in the Treatment of Mild to Moderate Active Stage Ulcerative Proctitis Between Once Daily and Twice Daily[J];中国全科医学;2016-11
5 DANG Hui-jiao;CAI Shao-hua;ZHANG Zai-hou;CHEN Wei-wei;LEI Li;First Department of State Guest, the General Hospital of PLA;;Effects of Traditional Chinese Medicine Enema combined with Metformin on the Fuctions of Platelet of Patients with Ulcerative Colitis[J];现代生物医学进展;2015-22
6 He Jiayu;He Yongmei;The People's Hospital of Pengzhou;;Mesalazine and Bifico in Ulcerative Colitis and Their Effects on Serum Inflammatory Cytokines[J];四川医学;2015-06
7 YI Rui;CHANG Juan;LIU Xiao-yan;HAO Nan;General Hospital of Beijing Military Command;Medical School of PLA;66011 Troops;;Expressions and Significance of TNF-α, IL-6 and IL-8 in Patients with Ulcerative Colitis at Different Degrees[J];现代生物医学进展;2015-14
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 ZHU Lei;SHEN Hong;SHEN Zhao-feng;ZHANG Lu;Base Office,Jiangsu Provincial Hospital of TCM;Department of Gastroenterology,Jiangsu Provincial Hospital of TCM;Department of Technology,Jiangsu Provincial Hospital of TCM;;Clinical analysis of risk factors associated in 135 patients with ulcerative colitis[J];中国中西医结合消化杂志;2017-06
2 GAO Meng-nai;ZUOU Hao;YU Zhu;CHEN You-da;Department of pharmacy,Cixi people's Hospital;Department of Gastroenterology,Cixi People's Hospital;;Effect of trimebutine maleate tablets on serum TNF-α,IL-23,ESR,D-D ulcerative colitis in patients with ulcerative colitis[J];中国生化药物杂志;2017-04
3 ZHAO Hongwei;LANG Xiaomeng;ZHU Yeshan;LIU Jianping;Department of Gastroenterology,Hebei General Hospital;;The effects of 1,25-dihydroxyvitamin D_3 on the immunologic mechanism of IL-23/IL-17 in the experimental colitis[J];疑难病杂志;2017-05
4 Angela C Baird;Dominic Mallon;Graham Radford-Smith;Julien Boyer;Thierry Piche;Susan L Prescott;Ian C Lawrance;Meri K Tulic;Faculty of Medicine and Dentistry, School of Medicine and Pharmacology, University of Western Australia;Department of Immunology, Fremantle Hospital;Royal Brisbane and Women’s Hospital, Brisbane;University of Nice Sophia-Antipolis;Department of Gastroenterology and Nutrition, l’Archet Hospital 2;School of Paediatrics and Child Health, University of Western Australia;International Inflammation network (in-FLAME) of the World Universities Network, University of Western Australia;Centre for Inflammatory Bowel Diseases, St John of God Subiaco Hospital;Mediterranean Center for Molecular Medicine (C3M)-INSERM U1065, Team 12;;Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy[J];World Journal of Gastroenterology;2016-41
5 CHEN Lu;ZHOU Zhongyin;Department of Digestive Disease,Wuhan Renmin Hospital;;The research progress of the pathogenesis of ulcerative colitis[J];疑难病杂志;2016-06
6 JI Jian-ping;OUYANG Xiao-yu;CHEN Jian-ping;YANG Yang;ZHOU Xiao-ming;Department of Infectious Disease,Longquan People′s Hospital;;Correlation between the serum level of 25-hydroxyvitamin D_3 and liver function, HCV-RNA load in patients with chronic hepatitis C[J];实用医学杂志;2016-09
7 MENG Hongjuan;HE Yi;ZHOU Ping;GAO Xuemei;ZHU Yilin;Department of Obstetrics,Wuhan First Hospital;;The effect of enoxaparin sodium on PIGF,25-hydroxy vitamin D and D-dimer in patients with early onset severe preeclampsia[J];疑难病杂志;2016-05
8 YU Hui-ling;LU Su-cai;MENG Jie;WANG Yang-yang;CHANG Ying;MEN Lu;GAO Rui;DING Jing;Department of Gastroenterology,Affiliated Hospital of Hebei University;;Clinical efficacy and safety of trimebutine combined with Shugan granule in the treatment of functional dyspepsia[J];中国临床药理学杂志;2016-06
9 Lei Zhu;Hong Shen;Pei-Qing Gu;Li Liu;Lu Zhang;Jia-Fei Cheng;Chang-Le Zhu;Hai-Peng Si;Base Office of Jiangsu Province Hospital of Traditional Chinese Medicine;Department of Gastroenterology,Jiangsu Province Hospital of Traditional Chinese Medicine;Technology Department of Jiangsu Province Hospital of Traditional Chinese Medicine;Department of Pathology,Jiangsu Province Hospital of Traditional Chinese Medicine;;Jianpi Bushen Qingchang Huashi Decoction combined with BMSCs for repairing intestinal barrier in a rat model of ulcerative colitis[J];世界华人消化杂志;2016-07
10 Yan Ren;Mei Liu;Jing Zhao;Feng Ren;Yu Chen;Jun-Feng Li;Jing-Yun Zhang;Feng Qu;Jin-Lan Zhang;Zhong-Ping Duan;Su-Jun Zheng;Artificial Liver Center, Beijing You An Hospital, Capital Medical University;Institute of Liver Diseases, Beijing YouA n Hospital, Capital Medical University;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College;;Serum vitamin D_3 does not correlate with liver fibrosis in chronic hepatitis C[J];World Journal of Gastroenterology;2015-39
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 CHEN Yu-sheng(Department of Pediatrics,The People’s Hospital of Huangchuan County,Huangchuan 465150,China);Evaluation of TNF-α on the efficacy of children with ulcerative colitis[J];河南医学研究;2010-02
2 ZHANG Yu-xia.Pathophysiology, Anhui Medical University,Hefei 230000,China;The role of interleukin-17 as an effector molecule against infection[J];国际免疫学杂志;2009-03
3 XIAO Nan-ping,OU-YANG Qin.Department of Gastroenterology,West China Hospital of Sichuan University,Chengdu(610041),China;The interleukin-23/17 axis and inflammatory bowel disease[J];国际消化病杂志;2008-03
4 YIN Wei-bing,ZHANG Xi-liang,XU Chun-jin(Department of Gastroenterology,The first people's Hospital of shangqiu,Shangqiu 476100,China);Influence of Hyperbaric oxygen on TNF-α and IL-6 in Patients with Ulcerative colitis[J];医学信息;2008-05
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