Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Difficult and Complicated Cases》 2017-05
Add to Favorite Get Latest Update

Protective effects of monascus on cerebral hemorrhage after intracerebral hemorrhage in rats

YI Jinying;WANG Gaiqing;WANG Juan;DUAN Shuna;LI Tong;DONG Liang;Graduate School,Shanxi Medical University;  
Objective To investigate the protective effect of monascin on cerebral hemorrhage and its optimal dose.Methods From March 2016 to October 2016 at the Shanxi Medical University neural electrophysiology laboratory selected120 male SD rats were randomly divided into sham operation group,model group,low dose monascin group,middle dose monascin group and high dose monascin group with 24 rats in each group.The rat model of cerebral hemorrhage was established by injection of Gollagenase type Ⅳ.The neurological deficit scores of Garcia were measured at 1,3,7 and 14 d after operation.Results Compared with the sham group,the scores of neurological deficits in model group,low dose group,middle dose group and high dose group were significantly decreased at 1,3,7 and 14 days(F = 181.705,F =494.229,F =226.576,F =24.726,P 0.01).The brain water content was significantly higher at 1 and3 d,respectively(F =21.781,70.036,P 0.05).The amount of iron deposition was significantly increased at 3,7 and 14 days(F = 21.426,118.122,107.773,P 0.05),and reached the peak at 7-14 days,and the number of PPAR-γ immunoreactive cells increased significandy at 1,3 and 7 days(F =3.394,F =28.622,F =14.12,P 0.05)(F =33.076,F =23.17,F =47.779,F =12.182,P 0.05).The number of SRA immunoreactive cells was significandy higher than that of the control group(F =22.283,F =511.092,F =51.811,F =31.060,P 0.05).Compared wiuS the model group,the Garcia score of the high dose group increased(P 0.05),the brain water content and the amount of iron stained particles decreased(P 0.05),and the high dose group PPAR-γ,Nrf2 and SRA The number of positive cells was significantly increased at 1,3 and 7 days(P 0.05),reached the peak at 3-7 days and decreased to the level of model group at 14 days.Conclusion High dose of monascus can increase the number of PPAR-γ,Nrf2 and SRA positive cells after cerebral hemorrhage,reduce brain edema and brain iron content after cerebral hemorrhage,and improve neurological deficits after cerebral hemorrhage.
【Fund】: 山西省基础研究计划项目(2014011041-5);; 2014年山西省卫生计生委科研项目(201301010)
【CateGory Index】: R743.34
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 8 Hits
1 SUN Xiaoli;WU Yue;QIN Min;LI Juan;Department of Internal Medicine,Central Hospital of Shangluo City,Shaanxi Province;;Clinical efficacy and changes in brain natriuretic peptide of patients with acute cerebral hemorrhage in treatment with edaravone[J];疑难病杂志;2016-12
2 Dong Yongjun;Tian Dezhou;Song Feixia;Department of Neurosurgery,Affiliated Hospital of Yan'an University;;Levels of serum matrix metalloproteinase-9 and tissue inhibitor of metalloprpteinase-1 in patients with cerebral hemorrhage and their correlations with cerebral edema[J];中国医药;2016-10
3 LIU Yashou;LIU Shixiang;Department of Neurology,Kunming General Hospital of Chengdu Military Area,Kunming Medical University;;The research progress of hyperbaric oxygen therapy of primary cerebral hemorrhage[J];疑难病杂志;2016-06
4 HAN Jianpeng;WANG Gaiqing;XU Yi;Department of Neurology,Shanxi medical University Second Hospital;;The effect evaluation of deferiprone,clioquinol on iron overload in intracerebral hemorrhage rats by MRI[J];中风与神经疾病杂志;2016-05
5 PU Guo-ming;Department of Neurology,the Central Hospital of Dazhou;;Clinical Effect of Blood Act and Stasis Remove Decoction on Acute Intracerebral Hemorrhage and the Impact on Serum hs-CRP Level and Plasma S100β Protein Level[J];实用心脑肺血管病杂志;2016-02
6 ZHAO Rui;WANG Gai-qing;Department of Neurology,Shanxi Medical University Second Hospital;;The effect of deferiprone on excess free iron accumulation、free radicals and functional outcome in intracerebral hemorrhage rats[J];中风与神经疾病杂志;2015-04
7 YIN Yong-feng;WANG Gai-qing;CHEN Yan-li.;Department of Neurology,Shanxi Medical University Second Hospital;;The effect of deferiprone on ferric Iron transporters and functional outcome in intracerebral hemorrhage rats[J];中风与神经疾病杂志;2014-02
8 MENG Shan-shan,WANG Gai-qing.(Department of Neurology,Shanxi Medical University Second Hospital,Taiyuan 030001,China);Role of ferric iron transporters on iron accumulation in brain after rat intracerebral hemorrhage[J];中风与神经疾病杂志;2013-04
Chinese Journal Full-text Database 5 Hits
1 LI Hui;QI Zheng-tao;ZHANG Yao;SONG Wen-ji;CHEN Kai-da;Department of ICU,The Third Affiliated Hospital,Guangzhou University of Chinese Medicine;;Effect of Chinese Herbal Medicine for Activating Blood Stasis on Acute Cerebral Hemorrhage and its Influence on Related Serum Indexes[J];现代生物医学进展;2018-14
2 LIAO Jun;HUANG Juan;SHI Yong-Mei;YU Qing-Ping;WU Wan-Feng;WANG Guo-Zuo;GE Jin-Wen;Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases,Hunan University of Chinese Medicine;;Effect of deferiprone on expression of iron transmembrane transport protein in hippocampus of cerebral ischemia-reperfusion rats[J];中国动脉硬化杂志;2018-06
3 Jing Tao;Tao Sun;Peng-xiang Bi;Ming-zhu Li;Department of Hyperbaric Oxygen, Hongqi Hospital of Mudanjiang Medical University;Hospital Office, Hongqi Hospital of Mudanjiang Medical University;Department of Neurology, Hongqi Hospital of Mudanjiang Medical University;Medical Imaging Institute, Mudanjiang Medical University;;Effect of hyperbaric oxygen on BDNF in patients with acute ischemic stroke[J];中国现代医学杂志;2018-04
4 YANG Jian;LI Pengfei;Department of Neurosurgery,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine;;Effect of ganglioside combined with edaravone on acute intracerebral hemorrhage and its effects on vascular endothelial growth factor and matrix metalloproteinase-9[J];白求恩医学杂志;2017-06
5 CUI Yue;HAN Lang;Department of Emergency,Central Hospital Affiliated to Shenyang Medical College;Specialist Clinic,Shengjing Hospital of China Medical University;;Neuroprotective effect of acetylglutamide combined with nalmefene on patients with acute cerebral hemorrhage[J];实用药物与临床;2017-12
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Xu Jiwei;Zhao Yaning;Li Jianmin;College of Post-graduate,North China University of Science and Technology;College of Rehabilitation and Nursing,North China University of Science and Technology;Dept of Neurosurgery,Affiliated Hospital of North China University of Science and Technology;;Main effect of edaravone on autophagy in hippocampal neurons of SAH rats[J];安徽医科大学学报;2016-04
2 YE Lu;YANG Shuangqiang;Department of Cardiothoracic Surgery,First Affiliated Hospital,Chongqing Medical University;;Sirtuin 3 inhibits cardiomyocyte apoptosis by reducing cytochrome C release in myocardiac H9c2 cells with calcium overload[J];细胞与分子免疫学杂志;2015-08
3 Gu Shuangshuang;Zhang Jun;Han Ling;Qian Jian;Li Qiming;Sha Dujuan;Emergency Department,the Affiliated Drum Tower Hospital of Nanjing Medical University;;Analysis of relevant factors for delayed cerebral edema and plasma matrix metalloproteinase 9 after intracerebral hemorrhage[J];中国脑血管病杂志;2015-06
4 ZHAO Rui;WANG Gai-qing;Department of Neurology,Shanxi Medical University Second Hospital;;The effect of deferiprone on excess free iron accumulation、free radicals and functional outcome in intracerebral hemorrhage rats[J];中风与神经疾病杂志;2015-04
5 GONG Yan-mei;LIU Wen-bing;SUN Xiao-ping;Ningbo Seventh Hospital;;The effects of hyperbaric oxygen on serum brain-derived neurotrophic factor and brain edema and neurological function in patients with acuteintracerebral hemorrhage[J];中风与神经疾病杂志;2015-01
6 LUO Juni;PENG Yu-qii;ZHAO Yangi;YAN Yangi;QUAN Li-mi;Department of Nephrology,Fulin Hospital of Mianyang;;Investigation on relationship between serum hs-CRP levels and bleeding volume,illness and cognitive impairment of patients with cerebral hemorrhage[J];临床医学;2014-12
7 ;Curative Efficacy Analysis of Integrated Treatment of Traditional Chinese Medicine and Western Medicine on Acute Cerebral Hemorrhage[J];中医临床研究;2014-27
8 Wang Dongsheng;Wang Honglian;Ge Ping;Mei Rui;Department of Neurology,401 Hospital of China-Nuclear-Industry;;The evaluation value of modified USA National Institutes of Health Stroke Scale score combined with bedside transcranial Doppler ultrasonography on the early prognosis of ischemic stroke[J];中国医师进修杂志;2014-22
9 ZHU Zhendan;MAO Xiang;LIU Baiyun;Clinical College of Anhui Medical University,General Hospital of Armed Police Forces;Department of Neurotrauma,General Hospital of Armed Police Forces;;Progress in MMP-9 and Traumatic Brain Edema[J];中华灾害救援医学;2014-06
10 CHEN Yanli;WANG Gaiqing;YIN Yongfeng;ZHAO Rui;Department of Neurology,the Second Hospital of Shanxi Medical University;;Influence of clioquinol on experimental cerebral hemorrhage in rats with ceruloplasmin expression[J];疑难病杂志;2014-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved