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《Chinese Journal of Difficult and Complicated Cases》 2017-07
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Effect of cinepazide on the levels of serum inflammatory factors,heart rate variability and heart function in patients with acute myocardial infarction

SU Xiaolin;LI Liyan;LI Lei;JI Shiqi;FAN Wei;LIU Zhen;ZHENG Fei;Department of Emergency,the first Hospital of Traditional Chinese Medicine and Western Medicine;  
Objective To investigate the therapeutic effect of cinepazide maleate on patients with acute myocardial infarction and the effect on the hs-CRP and IL-6 level.Methods Retrospective analysis of clinical data of patients with acute myocardial infarction from August 2014 to May 2016 in the hospital,according to the treatment methods,they were divided into cinepazide treatment group and conventional treatment group.The therapeutic effect of two groups were observed,and the differences of inflammatory factors,heart rate variability and cardiac function were compared between the two groups before and after treatment.Results The clinical effective rate of cinepazide treatment group was 96.9%,which was significantly higher than that of the conventional treatment group 87.1%(x~2=4.528,P =0.033);Before treatment,the levels of IL-6 and hsCRP were not significantly different between the 2 groups(t = 0.738,t=-0.132,P = 0.231,P = 0.448);after treatment,the cinepazide treatment group was lower than the conventional treatment group(t =7.706,t =8.291,P 0.01);Two groups of patients before treatment of heart rate variability levels have no significant difference(P 0.05),after treatment,the cinepazide treatment group' s SDNN,SDANN,RMSSD and PNN50(%) were higher than the control group(t=-6.299,t =-4.657,t =-7.744,t =-6.947,P 0.01);before treatment the level of SV,NT-proBNP,CTnI,SV and LVEF levels were had no significant differences between the 2 groups(t=0.036,t=0.687,t =0.057,t =0.085,P 0.05);after treatment,the cinepazide treatment group's SV and LVEF were higher than the control group(t=-5.992,t =-5.940,P 0.01),NT-proBNP,CTnI in the cinepazide treatment were lower than the conventional treatment group(t =57.370,t =17.407,P 0.01).Two groups of patients during the treatment showed no adverse reactions such as liver and kidney damage.Conclusion Cinepazide has better therapeutic effect on patients with acute myocardial infarction,it can significantly improve cardiac function and reduce hs-CRP and IL-6 level.
【Fund】: 2016年度北京市优秀人才培养青年骨干项目(2016000021469G198)
【CateGory Index】: R542.22
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