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《Chinese Journal of Difficult and Complicated Cases》 2017-07
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Effects of clopidogrel combined with aspirin on fibrinogen,D dimer and C reactive protein in patients with transient ischemic attack

LI Zhen;CAI Laixin;WU Zhi;LI Yuxin;WANG Qiunv;Department of Neurology,the Second People's Hospital Of Hainan Province;  
Objective To investigate the effects of clopidogrel combined with aspirin on fibrinogen,D dimer and C reactive protein in patients with transient ischemic attack.Methods Sixty patients of transient ischemic attack who received therapy from April 2013 to April 2016 were selected as research objects.According to random number table method,those patients were divided into the control group(n =30) and the observation group(n =30).The control group was treated with routine treatment,wliile the observation group also added clopidogrel combined with aspirin for treatment.Then Prothrombin time,Activated partial thromboplastin time,whole blood viscosity low cut,whole blood viscosity high cut,plasma viscosity levels,Fibrinogen,D dimer,C reactive protein were compared between the two groups.Results After treatment,the overall effective rate of the observation group was significantly higher than the control group(90.00%vs.66.67%,x~2=4.812,P =0.028).PT level in the observation group was significantly higher than that in the control group[(14.79 ±0.91) s vs.(12.49±1.31) s,t=7.898,P =0.000],APTT levels were significantly higher than those in the control group[(34.33 ±4.37) vs.(30.09 ±5.61)s,t=3.266,P =0.002].The level of whole blood viscosity was significantly lower than that of the control group[(5.18 ±1.03) mPa·s vs.(6.28 ±1.15) mPa·s,t =3.903,P =0.000].The level of whole blood viscosity was lower than that of the control group[(2.73 ±0.81) mPa·s vs.(3.97±0.94) mPa·s,t =5.474,P =0.000].Plasma viscosity was significantly lower than the control group[(0.96 ± 0.22) mPa·s vs.(1.56 ± 0.36) mPa·s,t = 7.789,P =0.000].The level of FIB in the observation group was significantly less than that in the control group[(2.11 ±0.59) g/L vs.(2.72±0.48) g/L,t =4.393,P =0.000].The level of D dimer in the observation group was less than that in the control group[(0.32 ±0.10) mg/L vs.(0.45 ±0.12)mg/L,t =4.558,P =0.000].The CRP level in the observation group was less than that in the control group[(3.51 ±2.91) mg/ml vs.(5.88 ± 1.51)mg/ml,t=3.960,P =0.000].There was no significant difference in the overall incidence of adverse reactions between the two groups(13.33%vs.16.67%,x~2 =0.131,P =0.718).Conclusion The use of clopidogrel combined with aspirin in the treatment of transient ischemic attack can effectively improve the coagulation function and hemodynamic parameters of patients,reduce fibrinogen,D dimer and C reactive protein,the effect is significant,it is worth promoting.
【CateGory Index】: R743.31
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