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《Chinese Journal of Difficult and Complicated Cases》 2017-07
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Effect of noninvasive positive pressure ventilation auxiliary joint naloxone with saffower yellower on severe cor pulmonale combination of respiratory failure

YAN Si;FU Zhiyue;LI Cui;YAN Guanghuan;MENG Xujun;Department of Respiratory Medicine,the People's Hospital of Qionghai City,Hainan Province;  
Objective To observe effect of noninvasive positive pressure ventilation auxiliary joint naloxone with saffower yellower on severe cor pulmonale combination of respiratory failure.Methods From October 2014 to September 2015,selecting 65 cases of severe cor pulmonale combination of respiratory failure patients in the hospital,according to the random number method,patients were divided into observation group(33 cases) and control group(32 cases).Control group were taken regular medicine comprehensive treatment with noninvasive positive pressure ventilation therapy,observation group were treated with naloxone with saffower yellower for treatment on the basis of control group.Before and after treatment,patients with arterial blood oxygen partial pressure,arterial blood(PaO_2),partial pressure CO_2(PaCO_2),blood pH value(pH),heart rate and breathing rate were tested.The clinical efficacy and adverse reactions were observed.Results After treatment,the total clinical efficacy rate in the observation was significantly higher than the control group[93.94%(31/33) vs.71.88%(23/32),x~2=23.633,P 0.01].PaO_2 of observation group was significantly higher than control group[(68.32 ±6.84) mmHg vs.(56.32 ±5.11) mmHg],PaCO_2 was significandy lower than the control group[(46.43 ±4.11) mmHg vs.(69.43 ±5.43) mmHg],the difference had statistical significance(t =7.994,t = 19.293,P 0.01).After treatment,the observation group' s heart rate,respiratory frequency were significandy lower than the control group[(101.11 ±4.32) times/min vs.(106.43 ±6.73) times/min;(21.43 ±0.25) times/min vs.(25.65 ±0.34) times/min,t =3.804,t = 57.135,P 0.01].Observation group and control group rate of adverse reactions had no significant difference(P 0.05).Conclusion Severe cor pulmonale combination of respiratory failure treated with noninvasive positive pressure ventilation auxiliary joint naloxone with saffower yellower can reduce PaCO_2,improve PaO_2,can reduce the heart rate and breathing rate,it is conducive to the improvement of clinical symptoms,clinical curative effect is good with high safety.
【CateGory Index】: R541.5;R563.8
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