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《Chinese Journal of Difficult and Complicated Cases》 2017-07
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Effects of calcitriol on thyroid hormone and bone mineral density in patients with hyperthyroidism

LU Xuliang;HOU Bo;CHEN Weiwei;He Tao;Department of Internal Medicine,Qianjiang Jianghan Oilfield General Hospital of Internal Medicine,Hubei Province;  
Objective To investigate the effects of calcitriol on thyroid hormone and bone mineral density in patients with hyperthyroidism.Methods One hundred and sixty cases of patients with hyperthyroidism were selected,who were treated in hospital from January 2015 to January 2017,and they were divided into the observation group(80 cases) and control group(80 cases).The patients of two groups were all treated with full rest,vitamin supplements,calcium,nutritional support and other conventional treatment.The patients of control group were treated with methimazole(oral,10 mg/time,1 time/d).On the basis of control group,the patients of observation group were treated with ossification triol capsules(oral,0.25μg/time,2 times/d).The patients of two groups were all treated for 6 weeks.The adverse reactions and changes of the levels of FT_3,FT_4,TSH,Ca,P,Mg,ALP,UCa,and femoral neck,L_(2-3),hip bone mineral density,Barthel index,pain score of two groups were compared.Results After the appropriate treatment,the levels of FT_3,FT_4 of two groups were all significantly lower than before(t =54.426,t =46.067,t =43.421,t =52.393,P =0.000,P =0.000,P =0.000,P =0.000),the levels of TSH of two groups were all significantly higher than before(t =71.415,t =76.752,P =0.000,P =0.000),but the difference between the two groups was not statistically significant(t =0.416,t =0.197,t = 1.036,P =0.339,P = 0.422,P = 0.151);The levels of Mg,femoral neck,L_(2-3),hip bone mineral density,Barthel index of the observation group were significantly higher than those of the control group(t =1.789,t =6.828,t =6.028,t =6.325,t =12.274,P = 0.038,P =0.000,P =0.000,P =0.000,P =0.000),the levels of UCa,pain score of the observation group were significantly lower than those of the control group(t =3.858,t = 29.080,P = 0.000,P = 0.000),but there were no significant difference in Ca,P and ALP between the two groups(t =0.537,t =0.308,t =0.792,P =0.296,P =0.379,P =0.215);There were nausea,diarrhea,rash,hypothyroidism,goiter,granulocyte deficiency,liver damage and other adverse reactions occurred in both two groups,but there were no statistically significant between the two groups(P 0.05).Conclusion Treating patients with hyperthyroidism,calcitriol can effective control the thyroid hormone levels,improve bone density and clinical symptoms of pain,and it is safe and reliable,which makes it have clinical promotional value.
【CateGory Index】: R581.1
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