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Effect of laparoscopic surgery and traditional laparotomy on serum inflammatory factors and long-term outcome in elderly patients with colon cancer

YANG Yi;WANG Cunchuan;GONG Jin;YANG Jingge;Department of Gastrointestinal Surgery,the First Affiliated Hospital of Jinan University;  
Objective To explore the influence of serum tumor necrosis factor levels and long term curative effect of traditional open surgery and laparoscopic surgery for elderly patients with colon cancer patients.Methods One hundred and twenty cases of colorectal cancer patients from the department of gastrointestinal surgery in the First Affiliated Hospital of Jinan University from January 2013 to June 2014 were randomly divided into experimental group and control group,with 55 cases in each group.The patients in the control group were treated with traditional open surgery;the patients in the experimental group were treated with laparoscopic radical resection of colon cancer.Serum tumor necrosis factorα(TNF-α),lnterleukin 6(IL-6),C reactive protein(CRP) between the two groups before and after treatment,amount of bleeding,operation time,intraoperative curative effect(hospital time,gastrointestinal function recovery time,the number of lymph node dissection,incision infection and pulmonary infection) and long term efficacy(intestinal obstruction;local recurrence,incision implantation and distant metastasis) level were compared and observed.Results Compared with before treatment,the TNF-α,IL-6 levels of patients in two groups were decreased,CRP levels were increased,the differences were statistically significant(P 0.05,P 0.01).Compared with the control group,the operation time was shorter,the amount of bleeding was less,TNF-α,IL-6and CRP levels were lower,the hospitalization time,gastrointestinal function recovery time were shorter,the incidence of pulmonary infection,intestinal obstruction were lower in the experimental group,the differences were statistically significant(P 0.01).In the meantime,compared with the control group,the lymph node clearance,incision infection rate,local recurrence rate,incision implantation incidence and distant metastasis incidence of the two groups shown no significant difference(P 0.05).Conclusion Compared with traditional surgery,laparoscopic colorectal cancer radical surgery can effectively reduce the patients' TNF-α,IL-6 level,increase the level of CRP and reduce the amount of bleeding,shorten the time of postoperative recovery of gastrointestinal function and postoperative hospital stay,reduce pulmonary infection,intestinal obstruction and other complications,in line with the concept of rapid rehabilitation surgery,worthy of in clinical application.
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