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《Chinese Journal of Difficult and Complicated Cases》 2017-07
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Clinical analysis of GnRH-a in the treatment of ovarian endometriosis cyst before laparoscopic surgery

LV Yan;LIU Hongying;YOU Lan;ZENG Ling;ZHANG Weihong;Department of Obstetrics and Gynecology,CITIC Huizhou Hospital;  
Objective To investigate the clinical value of gonadotropin releasing hormone analogue(GnRH-a) before laparoscopic surgery for ovarian endometriosis cysts.Methods From April 2012 to May 2015,90 cases of ovarian endometriosis cysts were treated in the department of obstetrics and Gynecology in CITIC Huizhou Hospital were enrolled.They were randomly divided into the observation group and the control group,45 cases each.The patients in the observation group received subcutaneous injection of GnRH-a before operation,and the control group did not use GnRH-a before operation.The relative indexes of perioperative period,hormone levels,follicular related indexes and follow-up results were analyzed and compared between the 2 groups.Results The operation time and recovery time of the observation group were shorter than that of the control group,and the amount of bleeding during operation was significantly less than that of the control group,and the difference between the 2 groups was statistically significant(P 0.01).The levels of hormones(LH,FSH,LH/FSH,E_2)in the observation group were significantly lower than those in the control group,and the difference between the 2 groups was statistically significant(P 0.01).The ovarian volume and the number of antral vesicles were significantly smaller in the observation group than in the control group,and the number of dominant follicles was significandy higher than that of the control group,and the difference between the 2 groups was statistically significant(P 0.01).The pain relief rate and pregnancy rate of the observation group were significantly higher than that of the control group,and the recurrence rate of the observation group was significantly lower than that of the control group,the difference between the 2 groups was statistically significant(P 0.05).Conclusion The use of GnRH-a injection before laparoscopic surgery for ovarian endometriosis cysts can reduce the difficulty of operation,improve the curative effect,and benefit the long-term prognosis.
【CateGory Index】: R713
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