Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Difficult and Complicated Cases》 2017-07
Add to Favorite Get Latest Update

Effect of Jinlida granule on serum nesfatin-1 level and islet β cell function in patients with pre-diabetes

CAI Jing;ZHAO Zhigang;ZHANG Lishuang;ZHANG Mengyao;DONG Lina;QIN Yingjun;Department of Endocrinology,the First Hospital of Shijiazhuang;  
Objective To observe the effect of Jinlida granule on serum nesfatin-1 level and islet fi cell function in treating patients with pre-diabetes.Methods Sixty of pre-diabetes patients were randomly divided into 2 groups,30 case in control group and 30 case in the observation group.Control group received diet and exercise therapy;the observation group therapy based on diet and exercise plus Jinlida granule treatment for 12 weeks.Before and 12 weeks after treatment,compared of the two groups nesfatin 1 and indicators of change.Results After treatment,the total effective rate of observation group was higher than the control group(80.0%vs.46.7%,x~2= 7.177,P =0.007).The observation group patients serum nesfatin-1,2hPG,HbA_(1c),FINs,HOMA-IR and BMI levels were lower than the control group(t =2.002,P =0.048;t=2.771,P =0.007;t =3.216,P =0.002;t =2.198,P =0.030;t =2.279,P =0.048;t =2.675,P =0.009);while the FPG,SBP,DBP,TC,TG,HDL-C and LDL-C levels of patients after treatment in the 2 groups had no significant change(t =1.432,P =0.155;t =0.221,P =0.825;t =0.086,P =0.933;t =0.593,P =0.554;t=0.881,P =0.380;t=1.168,P =0.246;t = 1.556,P =0.122).Conclusion It demonstrated that the Jinlida granule could correct the disorder of glucose metabolism in patients with pre-diabetes,decrease the level of serum nesfatin-1,and effectively improve the function of islet beta cells.
【Fund】: 石家庄市科学技术研究与发展指导计划(151461153)
【CateGory Index】: R259
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved