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《Chinese Journal of Difficult and Complicated Cases》 2017-12
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Effect of creatine phosphate combined with recombinant human brain natriuretic peptide on hemodynamic parameters and BNP levels in patients with coronary artery disease undergoing coronary intervention

GUO Lipeng;LIANG Bin;XU Baohua;XU Qingzong;Department of Cardiology,the Third People's Hospital of Dalian City;  
Objective To analyze and investigate the effect of creatine phosphate combined with recombinant human brain natriuretic peptide on hemodynamic parameters and BNP levels in patients with coronary artery disease undergoing coronary intervention. Methods Ninety cases of patients with coronary artery disease undergoing coronary intervention were selected,which were treated in hospital from September 2015 to September 2016,and they were divided into the observation group( 45 cases) and control group( 45 cases). The patients of control group were treated with recombinant human brain natriuretic peptide. On the basis of the control group,the patients of observation group were treated with creatine phosphate. The patients of two groups were all treated for 3 months in a row. Observe and compare the clinical treatment effect and the changes of hemodynamic parameters and BNP levels of two groups. Results After the appropriate treatment,the patients of the observation group got a total effective rate of 93. 3%,which was significantly better than the 77. 8% of the control group( χ2=4. 406,P = 0. 036); The serum MDA,CK-MB,c Tn I levels of the two groups were all significantly increased than before,and the patients of the control group got more significant increase( t = 6. 192,t = 7. 807,t = 5. 094,P = 0. 000,P =0. 000,P = 0. 000); The LVEF,FPV,SV levels of the two groups were all significantly increased than before,and the patients of the observation group got more significant increase( t = 5. 260,t = 5. 830,t = 6. 216,P = 0. 000,P = 0. 000,P =0. 000); The BNP levels of the two groups were all significantly decreased than before,and the patients of the observation group got more significant decline( t = 8. 157,P = 0. 000). Conclusion In the treatment of patients with coronary artery disease undergoing coronary intervention,creatine phosphate combined with recombinant human brain natriuretic peptide can play a role in myocardial reperfusion injury,significantly improve the patient 's hemodynamic parameters and BNP levels,which provides a certain clinical significance.
【CateGory Index】: R541.4
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