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《Chinese Journal of Difficult and Complicated Cases》 2017-12
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Correlation study of the levels of vitamin D with rennin and angiotensin aldosterone Ⅱ in type 2 diabetes

HE Jianqiu;ZHANG Rui;LU Yanan;HAN Guiyan;Department of Endocrinology,Affiliated Hospital of Chengde Medical University;  
Objective To investigate the correlation of the levels of vitamin D with rennin,angiotensin Ⅱ in type 2 diabetes. Methods One hundred and seven cases of patients with type 2 diabetes,as defined by the WHO criteria were enrolled as object of study. They were divided into control group( ACR 30 μg/mg),microalbuminuria group( 30 μg/mg ACR 299 μg/mg) and clinical proteinuria group( ACR≥299 μg/mg) according to urinary albumin to creatinine ratio. The levels of vitamin D,rennin concentration and angiotensin II were detected. Results The results showed that levels of vitamin D of control group,microalbuminuria group and clinical proteinuria group were decreased [( 24. 52 ± 3. 87) ng/ml,( 22. 59 ±4. 00) ng/ml,( 16. 60 ± 5. 23) ng/ml,F = 29. 85,P 0. 01 ],while the concentration of rennin [( 13. 52 ± 3. 80) pg/ml,( 17. 15 ± 5. 02) pg/ml,( 21. 04 ± 4. 15) pg/ml,F = 25. 29,P 0. 01] and angiotensinⅡ[( 157. 16 ± 40. 88) pg/ml,( 208. 80 ± 58. 77) pg/ml,( 259. 37 ± 52. 90) pg/ml,F = 34. 05,P 0. 01]were increased,the differences were statistically significant( P 0. 05),the levels of vitamin D and rennin concentration were negatively correlated( r =-0. 792,P 0. 05),and the levels of vitamin D and angiotensinⅡwere negatively correlated( r =-0. 870,P 0. 05). Conclusion The more serious the condition of type 2 diabetic nephropathy,the lower the level of plasma vitamin D,and the increase of renin and angiotensin Ⅱ levels.
【Fund】: 承德市科学技术研究与发展计划项目(20132046)
【CateGory Index】: R587.2;R692.9
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