STUDY ON THE TERATOGENICITY OF ERDOSTEINE
WANG Qu—nan, She Su—zhen, Wei Ling—zhen, Sun Mei—fang (Dept of Toxicology, Anhui Medical University, Hefei 230032, China)
Purpose: To research the teratogenic effect of Erdosteine on SD rats. Methods: The animals were divided into negative and positive control and two experiment groups which were oraly given by Erdosteine from Day 6 to Day 15 of gestation in dosages of 1.0g/kg and 0.1g/kg respectively. The body growth gains of gestation mice, the numbers, body weight, length and tail length in living fetus and some indicators of embryonic formation were measured. Results: There were no significant differences as compared with negative control groups. Besides, the deformity of the appearances, internal organs and bone in fetal mice was not found. Conclusion: The results indicated that Erdosteine bad no teratogenic effect on SD rats in this experiment.
【CateGory Index】： R96