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《亚太热带医药杂志(英文版)》 2008-01
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Influence of a-tocopherol on nickel induced alteration of serum lipid profile in male albino rats

Gupta AD1,Dhundasi SA1,Dhara PC2,Das KK1 1 Department of Physiology,Al-Ameen Medical College,Bijapur 586108 Karnataka,India 2 Department of Human Physiology & Community Health,Vidyasagar University,Midnapur(West) 721102,West Bengal,India  
We studied the effect of the simultaneous treatment withα-tocopherol(100 mg / kg;im) and nickel sulfate (20 mg/kg,ip) on nickel-induced changes in serum lipid profiles.Nickel-treated rats showed a significant increase in serum LDL cholesterol,total cholesterol,triglycerides,and a significant decrease in serum HDL cholesterol. Simultaneous administration ofα-tocopherol with nickel sulfate improved LDL-cholesterol and HDLcholesterol level when compared with rats receiving nickel sulfate alone.The results indicate thatα-tocopherol is beneficial in preventing nickel-induced lipid profile alterations.
【Fund】: Defence Institute of Physiology and Allied Sciences New Delhi DRDO Ministry of Defence Government of India No.TC/ 260/ TASK- 91(KKD) / DIPAS/2004 dt.07/06/2004.
【CateGory Index】: R96
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