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《Progress In Pharmaceutical Sciences》 2001-01
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The Resolution of Enantiomic Drugs Using Protein as Chiral Stationary Phase in HPLC

ZHANG Ling xia, LIU Jing, HU Yu zhu (Department of Analytical Chemistry,China Pharmaceutical University,Nanjing 210038,China)  
Proteins as chiral stationary phases(CSP) in high performance liquid chromatography were widely used in the resolution of enantiomic drugs, for CSP can provide multiple interactions and multiple recognition sites. In this paper, the characters and applications of proteins as CSP in enantiomic drug resolution were reviewed, and the factors influenting the results of drug resolution, such as state of stationary phase, pH value of mobile phase ,organic modified agent and temperature of the column were emphasized.
【CateGory Index】: R914
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