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《Progress in Pharmaceutical Sciences》 2017-01
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Progress in Metal Complex-based Luminescent Probes for Small Biological Molecules

ZHANG Chen;GUAN Ruilin;CHEN Yu;JI Liangnian;CHAO Hui;School of Chemistry and Chemical Engineering, Sun Yat-Sen University;  
There are a variety of endogenous bioactive substances in living organisms that are involved in conducting signals and regulating metabolism. Normally, the intracellular environment continues to change, but dynamic balance is maintained for the space-time distributions of endogenous bioactive small molecules. However, when their species and concentrations are beyond the ranges needed by biological processes, cellular viability will be affected and many diseases may develop, even including tumor and cancer. Thus, tracking and visualizing their activities in organisms are important for understanding living processes and pathogenic mechanisms. Compared with traditional organic dyes, metal complexbased luminescent(fl uorescent or phosphorescent) probes are advantageous in photo-stability and easy modulation of physiological function, becoming a research hotspot in the fi eld of tracking and imaging of small biological molecules. In this paper, metal complex-based probes for living systems were classified and summarized according to their targets, and their future applications in bio-imaging were forecasted. We hope that this review could provide reference for the design and synthesis the novel metal complex-based probes, and improve the understanding of probe action and cancer treatment at molecular level.
【Fund】: 国家自然科学基金(No.21471164;No.21501201;No.21525105)
【CateGory Index】: O641.4;O657.3
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