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《Progress in Pharmaceutical Sciences》 2017-01
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Research Progress in Small-Molecule Fluorescent Probe for Potassium Channels

ZHANG Xiaomeng;DU Lyupei;Department of Medicinal Chemistry, School of Pharmacy, Shandong University;  
Potassium channels are the most diverse and widely distributed type of ion channel. Because of their diverse physiological functions, potassium channels have become drug targets for many diseases. In recent years, many drugs with different chemical structures have been withdrawn from the market because of their blockage of potassium channels and subsequent severe cardiac toxicity. As a result, screening of potassium channel inhibitory activities of small-molecule drugs are facing great challenges. This article introduced the research progress in small-molecule fluorescent probes for potassium channels, and summarized their mechanisms, hoping to provide ideas for the future design of small-molecule fluorescent probes and promote their use in high throughput screening of candidate drugs as well as in the in vivo imaging and detecting of potassium ion channels.
【CateGory Index】: R91
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