Study on Furoxan Derivatives as a class of NO donor in Cardiovascular Effect
Mu Li Hua Weiyi Peng Sixun Division of Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009
The furoxan (Furazan oxide; 1,2,5 oxadiazole 2 oxide) derivatives possessing wide ranging biological activity have caused much discussion and controversy since its first preparation. The results obtained in the study of the furoxan derivatives as NO donor were reported in the present paper. It was noted that some fused benzofuroxan derivatives, 3,4 disubstituted furoxancarboxamides had the distinct vasodilation effects and 4 methyl 3 (arylsulfonyl)furoxans possessed the most potent inhibiting activity of platelet aggregation among all derivatives concerned. The technique of “medicinal chemical hybridization” or “symbiotic approach” in the design of new drugs for antihypertensive treatment was introduced, and the resulting hybrids, some furoxan analogues of prazosin and nifedipine were described. The mechanism releasing NO from furoxans was also discussed.