Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《药学进展》 1997-01
Add to Favorite Get Latest Update

Recent Advances in HIV Protease Inhibitors

Leng Qibin Department of Virology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing 100050  
HIV Protease plays a crucial role in HIV replication and maturation. Inhibition of this enzyme leds to the formation of noninfectious progeny virus in vitro.Its inhibitors were widely studied for chemotherapeutic agents in the treatment of AIDS. The accumulative knowledge about physiology, chemistry, steric structure and substrate specificity of the enzyme facilitated the design discovery of its inhibitors. Three compounds have been authorized as the clinical drugs till now. This review aims to summarize progresses of this research in the past years.
【CateGory Index】: R512.91
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 2 Hits
1 Zhang Ron-hua~1,Lu Fang~1,Zhu Zhi-liang~2(Department of Chemistry,Tongji University,Shanghai,200092,China;College of Environmental Science and Engineering,Tongji University,Shanghai,200092,China);Synthesis of thiazole derivatives[J];Chemical Research and Application;2006-02
2 Le Zhanggao, Huang Guolin (Department of Applied Chemistry East-China Geological College,Linchuan 344000);ANTI-HIV BIOACTIVATED NATURAL PRODUCTS[J];Natural Product Research and Development;1999-04
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 PAN Ji hong 1, YANG Chao ying 2, ZAHNG Guo yuan 2 (1.College of Life Science, Anhui Normal University, 241000, Wuhu, Anhui, China;2. Department of Biology and Chemistry, Anhui Mechanical and Electrical College, 241000, Wuhu, Anhui, China);A STUDY ON MAKING CORIOLUS VERSICOLOR HEALTH BEVERAGE[J];JOURNAL OF ANHUI NORMAL UNIVERSITY(NATURAL SCIENCE);2000-03
2 XU Xuan1*, LUO Yi fan2, XU Zhi guang1, LI Wei hua1 1.Department of Chemistry, South China Normal University, Guangzhou 510631, P.R.China 2.Department of Natural Drug, Sun Yat sen University of Medical Sciences, Guangzhou 510089, P.R.China;Relationship between Electronic Structure and Antitumor Activity of Indirubin Derivatives[J];Chinese Journal of Cancer;2001-12
3 DENG Bai_wan CHEN Wen_qiang (Bio_resources key Laboratory of Shaanxi Province, Hanzhong Teachers College, Hanzhong 723000, Shaanxi, China);Study on Accumulation of selenium in Polystictus Versicolor in Submerged Culture[J];Amino Acids & Biotic Resources;2000-04
4 XU Shu-xia~1 SONG An-dong~1 ZHANG Shi-min~1 WANG Lun-ji~2 MIN Hang~3 WU Kun~1 (1 College of Life Science, Henan Agricuhural University,Zhengzhou 450002,China;2 College of Food & Bioengineering,Henan Science & Technology University,Luoyang 471000,Henan,China;3 College of Life Science,Zhejiang University,Hangzhou 310029,China);Hydroquinone degradation by using laccase and filtrate from C.Versicolor[J];Journal of Safety and Environment;2007-06
5 RAO Gang,TANG Xue-weu (Department of Internal Medicine,Banan District People's Hospital,Chongqing 401320,China);Effect of coriolus versicolor intracellular polysaccharide(CVICP) on blood lipid in patients with hyperlipidemia[J];Chongqing Medicine;2007-13
6 QI Yu-Hua, XU Lu(Changchun Institute of Applied Chemistry, Academia Sinica, Changchun 130022, China)LIU Zhong-Ying(Norman Bethune University of Medical Sciences, Changchun 130023, China);Structure-activity Relationships for Antiplasmodial Activity Among Aminoquinolines[J];CHEMICAL RESEARCH IN CHINESE UNIVERSITIES;2000-02
7 WANG Peng1,XU Hao2,HUANG Wen-long1(1.Center of Drug Discovery,China Pharmaceutical University,Nanjing 210009,China;2.College of Science Nanjing University of Technology,Nanjing 210009,China);Current situation and tendency of researches on anti-HIV drugs[J];Strait Pharmaceutical Journal;2008-01
8 GUO Wei-yun~1,YAO Zhao-yang~2,SHAO Qiang~3,LI Wen-qiang~4, LI Zong-yi~3(1.Department of Life Science and Technology,Xinxiang Medical College,Henan Xinxiang 453003,China;2.School of Basic Medicine,Xinxiang Medical College,Henan Xinxiang 453003,China;3.College of Life Science,Henan Normal University,Henan Xinxiang 453007,China;4.College of Life Science,Hebei Normal University,Hebei Shijiazhuang 050016,China);Research on the Conditions for Laccase Production from Trametes versicolor[J];;2006-06
9 Liu Shushen;Yan Wanping;Cao Chengzhong;Li Zhiliang(Department of Applied Chemistry,Guilin Institute of Technology,Guilin 54l004)(Department of Chemistry,Xiangtan Teacher's College,Xiangtan 411100)(Institute of Chemistry and Chemical Engineering,Hunan Univ;PREDICTION OF PHYSICAL PROPERTIES OF ALKANES BY NOVEL MODIFIED BACK PROPAGATION NEURAL NETWORK[J];Journal of Chemical Industry and Engineering(China);1998-02
10 Yao Yuyuan;Xu Lu;Yang Yiqiu;Yuan Xiushun(Changchun Institute of Applied Chetmistry,Chinece Academy of Sciences,130022);A NEW KIND OF TOPOLOGICAL INDEX AND ITS APPLICATIONS 0N STRUCTURE-PROPERTY RELA- TIONSHIPS OF ORGANIC COMPOUNDS[J];ACTA SCIENTIAE CIRCUMSTANTIAE;1994-01
【Secondary References】
Chinese Journal Full-text Database 3 Hits
1 YANG Jing song West China School of Pharmacy, Sichuan University, Chengdu 610041,China;PROGRESS IN STUDIES OF ANTI-HIV COUMARINS[J];West China Journal of Pharmaceutcal Sciences;2001-04
2 YANG Zhan-nan~(1,2),YANG Xiao-sheng~(1,* ) ce and Chinese Academy of Sciences,Guiyang,Guizhou 550002,China;2. Research and Development Center of Fine Chemicals,Guizhou University, Guiyang,Guizhou 550025,China);Advances in study on the sulphureous substance of the natural plants[J];Journal of Guizhou Normal University(Natural Science);2004-01
3 LI Yun,ZHOU Zheng-zhi ( Chengdu Diao Pharmaceutical Group Co.Ltd, Chengdu 610041);STATUS AND PROSPECT OF TRADITIONAL CHINESE MEDICINE IN THE PREVENTION AND TREATMENT FOR AIDS[J];Natural Product Research and Development;2003-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved