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《The Journal of Medical Theory and Practice》 2000-01
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Pathological Changes in Heart 、Lungs、Spleen、Liver、Kidneg of Rats by Using Prednisone

Militarg hospital of NO 456,Jinan(250031) Liu Yanqiu,Wang Yunfeng,Chen Baohai  
To study the pathological changes in heart, Lungs, spleen Liver, kidneys of rats in therapy of prednis one,28 Wistar rats were divided into two groups;test group and central group each had 14 rats. The rats in test group were fed with water containing prednisone(2mg/kg/d per fat),and rats in central group were fed with water with nothing ,ten week Later,Killed the rats to study,There was no changes in heart. Lungs, spleen, Liver,kidneys in central group under microscope,and also in heart,lungs in test group. The liver,kideneys became hyperemia in test group, especial in spleen, hemosiderin deposited there. The results showed that normal dosage of prednisone may do some harm to liver,spleen and kidneys. We should adjust the dosage of prednisone in time,adjust the mode and tmie of drug using according to different disease,in order to decrease the side offec-tion.
【CateGory Index】: R965
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