Changes of Plasma Fibrinogen and Serum K+ Concentrationsin Patients with Essential Hypertension Before and After Mornopril Treatement
Department of cardiology,Gaozhou people's Hospital,Gaozhou(525200) Zhu Xiulong
To investigate the changes of plasma fibrinogen and serum K+ and concentration in patients with essential hypertension before and after antihypertensive trentment. plasma fibrinogen and serum K+ concentrations were measured with therncoprepilatic turbidimetry automatic biochemical analysis apparatus in 23 noroten-sive controls and 53 patients with essential hypertension before and after 12 weeks of treatment with momopril. The baseline concentrations of plasma fibrinogen were significantly higher in hypertensive patients than in nomo-tonsive controls(4. 32±0. 46g. L-1vs. 3. 5±0. 34g. L-1, P 0. 01). while the levels of serum K+ were lower in hypertensive patients than in normotensive controls(3. 50±0. 34mmol. L-1vs. 3. 7 ±0. 28mmol. L-1, P 0. 01). After 12 weeks trentment of mornopril,plasma fibrinogen concentrations had fallen to 3. 24 ±0. 35g. L-1 ( P 0. 01). While serum K+ concentrations didn't change, plasma fibrinogen levels are higher while serum K+ concentrations are lower in patients with hypertension. Momopril can decrease blood presure as well as plasma fibrinogen concentrations,but doesn't change the levels of serum K+.