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The Effect of Chitooligosaccharides on Preventing the On set of Diabetes in NOD Mice

CAO Zhaohui,LI Bangliang,QIAO Xinhui,et al.Nanhua university,Hengyang of Hunan Province 421001  
Objective:To explore the effect of chitooligosaccharide s on preventing the onset of diabetes in NOD mice.Methods: 5-week-old NOD mice were divided into a diabetic preventing group and a diabetic control gr oup.The preventing group and the control group received 3% chitooligosaccharides and cool water as drinking water for 15 weeks respectively.Then these mice were measured blood glucose and body weight.At the end of the experiment,the inciden ce of diabetes was investigated in NOD mice,insulitis was observed by HE stainin g.Results:In the control group,these 12-week-old mice appeared hyper g lycemia.However,in the preventing group,only a few mice had appeared hyperglycem ia by the end of the test.The blood glucose level in the diabetic preventing group was significantly lower than that in the control group(P0 01).The i ncidence of diabetes in the preventing group was 25% which was lower than 79% in the control group (P0 05),and the degree of insulitis was also less tha n that in the control group (P0 05).Conclusion:Chitooligosacc harides prevents NOD mice from developing type 1 diabetes,which may be related t o immunopotentiation and antioxidation of chitooligosaccharides.
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