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Curative Effect of Mirtazapine for Senile Unstable Angina Pectoris Combined with Depression

LUO Qilong,LIAN Qihui,GUANG Hui. Dapeng Hospital of Longgang District Shenzhen Ctiy,Guangdong Province 518120  
Objective: To evaluate the clincal effect of mirtazapine for supportive treatment of senile unstable angina pectoris combined with depression.Methods:68 cases of senile unstable angina pectoris combined with depression were divided into two groups.The control group was treated with routine drugs,and the treated group was given mirtazapine(30mg/d),in addition to the routine treatment.The duration of observation was 6 months in two groups.Results:In treatment group there were 29 cases breaking out one or less time and 5 cases breaking out more than 2 times weekly. In control group there were 9 and 25 cases having aforementioned conditions respectinely.The difference in two groups was significant( P 0.01).In treated group there were 27 and 7cases given 2 and more than 2 mg of nitroglycerine a week,respectively,and more than 2mg of nitroglycerine a week,respectively,and in control group there were 10and 24 cases.Both groups differed remarkebly( P 0.01).In treated group the drop times of ST cector by the end of periods of 3 and 6 months were(73±15)and(51±15),respectively,and in control group the drop times were(101±23) and (118±24),respectively.The difference between two groups was great significant( P 0.05).The rehespitalized patients were 2 and 7 in treated group and in control groups( P 0.05).Conclusion: As a supportive drug against depression,mirtazapine is very effective for senile unstable angina pectoris combined with depression.
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