Clincal Observation of Curative Effect of Low Molecular Heparin and Clopidogrel in Transcient Ischemic Attack.
SHI Yan LIU Hua.The Affiliated Hospital of the Medical University of Guangdong,Guangzhou City,Guangdong Province 510080
Objective:To observe the effect and safty of low molecular heparin and clopidogrel in treating transcient ischemic attack. Methods: 60 patients with TIA were enrolled in this study and randomly distributed into treatment group and control group, each group contained 30 patients . Treatment group were administered low melecular heparin 0.4mL, injected hypodermic, twice daily for 10 days,followed by clopidogrel 75mg, once daily orraly for half one year.Control group gave FuFangDanShen injection 20mL once daily intravenously for 14 days and intestine-dissovable Asprin 0.1 once daily at the same time for half year. The two group also administered CDPC、ATP and COA etc. Results:TIA attacks were controlled completely within 10 days in treatment group, no re-attacks in 29 cases after half a year's follow-up(29/30), the efficacy rate was reached up to 96.67%,none of 30 patients developed cerebral infarction and cerebral hemorrhage. In control group,TIA attacks were controlled completely in 15 of 30 cases(50%), 11 patients developed cerebral infarction . There was a significant differences between the two group(P0.001).Conclusions: Low molecular heparin and clopidogrel are effective and safe in treatment of TIA, the reoccurrence rate is greatly decrease and no obvious drug side effect was observed.