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The Combination of Compound ZaoFan Pill and Androgen in the Treatment of Chronic Aplastic Anemia

HUANG Wangxiang*, LUO Ling,CHEN Jianxia, et al.*The Central Hospital of Longgang, Shenzhen,Guangdong Province 518116  
Objective:To explore the therapeutic effectiveness of combination of compound Zaofan pill and androgen in the treatment of chronic aplastic anemia (CAA). Method: Androgen alone and its combinaticn with compound Zaofan pill was compared in the treatment effect of CAA by a randomized controlled clinical trial. Results: The efficacy of androgen combined with compound Zaofan pill(91.23%)was higher than that of androgen alone(58.16%). Therapeutic effectiveness of the combination treatment for the patients with positive and with negative peripheral blood mononuclear cells (PBMNCs) inhibiting normal colony formation unit-granlocyte and macrophage (CFU-GMO) test showed a significant difference (P0.05). Conclusion:Combination of Androgen with compound Zaofan pill has a much better efficacy than that of androgen alone in the treatment of CAA. The patients' PBMNCs inhibiting normal CFU-GM growth test can be used as an index of the treatment outcome . The side effects of the combination therapy are low and tolerable.
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