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Study of Omeprazole Triple Therapy for the Treatment of Active Peptic Ulcer

LI Renji*,WU Xiuying, HUANG Xiaofen*.*Clinical Institute of Zhongkai agricultural Technology Cllege, Guangzhou City,Guangdong Province 510225  
Objective: To study the effect and compliance of Omeprazole triple therapy on the treatment of helicobacter pylori (H. pylori) related active pepticulcer. Methods: Ninety-six patients with active petic ulcer confirmed by gastroendoscopy were divided into two groups. GroupOAC: 40 patients received Omeprazole 20 mg twice daily, Amoxicillin 0.5g three times a day, Clarithromycin 0.25g twice daily and Group RAM: 56 patients with Ranitidine triple therapy for 2 weeks. After 4 weeks treatment,gastroendoscopy was reexamined. Results: Ulcer healing rates were 92.5% and 87.5% in Group OAC and Group RAM,(P0.05). Eradication rates of H. pylori were 87.5% and 89.3% in Group OAC and Group RAM, P0.05. There was no obvious differences. Group OAC was better than Group RAM on symptom cortrol, and compliance. Conclusion: The effect of omeprazole triple therapy better than Group RAM, and the side effect was fewer.
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