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The Influence of Nebulizing Inhalation of Ambroxol Hydrochloride and Ipratropium Bromide in Treatment of Chronic Obstructive Pulmonary Disease

XIE Feng.Department of Internal Medicine,The Dongsheng Hospital of Zhongshan City,Guangdong Province 528414  
Objective:To study of the role of ambroxol hydrochloride and ipratropium bromide in treatment of chronic obstructive pulmonary disease(COPD).Methods:86 patients with COPD were randomly divided into two groups,ipratropium bromide group and combine group.Ipratropium bromide group were treated with nebulizing inhalation of ipratropium bromide,while combine group were treated with nebulizing inhalation of ambroxol hydrochloride and ipratropium bromide.Measuring oxyhemoglobin saturation、FEV1、mean hospitalization days of two groups.Results:FEV1 difference of ipratropium bromide group before or after therapy was(0.324±0.102)L,combine group was(0.468±0.124)L(P0.05).Total efficiency of ipratropium bromide group was 81.4%,combine group was 88.4%(P0.05).Conclusion:Combined use of ambroxol hydrochloride and ipratropium bromide has synergistic action for treatment of COPD.
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