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《Acta Pharmaceutica Sinica》 1986-05
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STUDIES ON PHARMACOKINETICS AND PHARMACODYNAMICS OF FUROSEMIDE IN MAN

ZHU Jia-Bi (Department of Pharmaceutics, Nanjing College of Pharmacy, Nanjing)  
The pharmacokinetics and pharmacodynamics of furosemide were studied. Four healthy male volunteers between ages of 30 to 45 years were selected for the studies. Each subject received 5,10,20 and 40 mg of furosemide by oral adminitration. The urinary excretion data were analyzed by PDP-11 computer with a nonlinear least square model-fitting program designed by the author. Disposition of the drug in man can be described by two compartment open model. The pharmacokinetic parameters were as follows: k_a=2.5115 h~(-1), k_(12)=0.6441 h~(-1), k_(21)=0.7096 h~(-1), k_(el)=1.6018 h~(-1), t=0.2053 h. Total increments of urine volume and urinary Na~++K~+ in 3 h after the drug administrations Were linearly related with the logarithm of corresponding doses. Quantitative relationship of pharmacokinetics and pharmacodynamics of furosemide can be characterized by Hill equation. Another equation relating the drug excretion rates and diuretic actions was inducted and by this equation the clockwise hysteresis of furosemide action can be simulated.
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【References】
Chinese Journal Full-text Database 1 Hits
1 LIU Xiao-Quan, HUANG Sheng-Kai, LU Hong, YANG Jin-Yu Dept Pharmacology, China Pharmaceutical University, Nanjing 210009;Combined pharmacokinetic and pharmacodynamic model for furosemide in rabbits[J];Chinese Journal of Pharmacology and Toxicology;1991-02
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 LIU Xiao-Quan, HUANG Sheng-Kai, LU Hong, YANG Jin-Yu Dept Pharmacology, China Pharmaceutical University, Nanjing 210009;Combined pharmacokinetic and pharmacodynamic model for furosemide in rabbits[J];Chinese Journal of Pharmacology and Toxicology;1991-02
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 Yuan Yi-seng,Wu Chuang & Cai Ming-rui, General Hospital of Nanjing Command, PLA.;DETERMINATION OF FUROSEMIDE IN HUMAN PLASMA AND URINE BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY[J];Chinese Journal of Chromatography;1985-S1
2 Yang Jinyu, Liu Xiaoquan~1, Huang Shengkai~1 Analysis and Computer Center; ~1Department of Pharmacology;Computer Program for the Effect Parameters of Combined Pharmacokinetic and Pharmacodynamic Model[J];Journal of China Pharmaceutical University;1990-03
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