Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Pharmaceutica Sinica》 1986-05
Add to Favorite Get Latest Update

NEOLIGNANS FROM PIPER HANCEI MAXIM

HAN Gui-Qiu, LI Shu-Ming, LI Chang-Ling, ~*J P Springer, ~*S B Hwang and ~*M N Chang (College of Pharmacy, Beijing Medical University, Beijing; ~*Merck Sharp & Dohme Research Lab. USA)  
Piper hancei Maxim, Family Piperaceae, has been used in Chinese folk medicine for the treatment of rheumatoid arthritis and asthma. A new neolignan, hancinone (Ⅲ) was isolated together with two known neolignans, kadsurenone (Ⅰ) and denudatin B (Ⅱ). The structure of hancinone (Ⅲ) was established as (7. S, 8 R, 3′S) -1′ - allyl-3′-methoxy-7- (3,4 -methylenedioxyphenyl) - 8 - methyl-7, 8, 3′, 6′-tetrahydro-6′-oxobenzofuran through interpretation of the spectral data (UV, IR, NMR and MS) and the results of a single crystal X-ray analysis.Kadsurenone (Ⅰ) and denudatin B (Ⅱ) were isolated for the first time from this plant.In the PAF receptor binding assay and the test of platelet aggregation, denudatin B (Ⅱ) was substantially less active than kadsurenone (Ⅰ), whereas hancinone (Ⅲ) showed' no PAF antagonistic activity.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 4 Hits
1 LI Shu-Ming, HAN Gui-Aiu, B. H. Arison~* and M. N. Chang~* (School of Pharmaceutical Sciences, Beijing Medical University, Beijing; ~* Merck Sharp & Dohme Research Lab, USA);STUDIES ON CHEMICAL CONSTITUENTS OF PIPER HANCEI MAXIM (Ⅱ)[J];Acta Pharmaceutica Sinica;1987-03
2 GQ Han, LH Wei, CL Li, L Qiao, YZ Jia and QT Zheng~* (School of Pharmaceuticat SSciences, Beijing Medical University, Beijing 100083;~*Institute of Materia, Chinese Academy of Medical Sciences, Beijing 100050);THE ISOLATION AND IDENTIFICATION OF PAF INHIBITORS FROM PIPER WALLICHII (MIQ.) HAND-MAZZ AND P. HANCEI MAXIM.[J];Acta Pharmaceutica Sinica;1989-06
3 Y Ma, GQ Han and YY Wang (National Laboratory of Natural and Biomimetic Drugs, Beijing Medical University, Beijing 100083);PAF ANTAGONISTIC BENZOFURAN NEOLIGNANS FROM PIPER KADSURA[J];Acta Pharmaceutica Sinica;1993-05
4 ZHOU Liang1, YANG Jun-shan1, TU Guang-zhong2(1.Institute of Medicinal Plant Development, Chinese Academy of Sciences and Peking Union Medical College, Beijing 100094,China;2.Beijing Institute of Microchemistry Research, Beijing 100060,China);Study on chemical components of Piper hancei[J];Chinese Pharmaceutical Journal;2005-03
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Yu Xiangmin,Wang Wenqing,Wu Cuijiao,] et al\ Department of Histology and Embryology, Qingdao Medical College, Qingdao 266021\;;CYTOCHEMICAL AND ULTRASTRUCTURAL STUDIES ON THE INFLUENCE OF KADSURENONE UPON THE IMPLANTATION OF MOUSE EMBRYOS[J];;1999-01
2 Wu Mei,Wang Wenqing,Wu Cuijiao, et al\ Department of Histology and Embryology, Qingdao Medical College, Qingdao 266021\;;THE INFLUENCE OF KADSURENONE UPON BLASTOCYST IMPLANTATION IN MICEIMMUNOHISTOCHEMICAL STUDIES[J];;1999-01
3 School of Pharmaceutical Sciences Han Gui-qiu, et al;THE ISOLATION AND IDENTIFICATION OF PAF RECEPTOR ANTAGONIST FROM PIPER WALLICHII (MIQ) HAND-MAZZ[J];;1987-04
4 Han Guiqiu,et al Research Laboratories of Natural and Biomimetic Drugs;THE STUDIES OF NATURAL PAF ANTAGONISTIC NEOLIGNANS FROM PIPER GENUS AND THEIR STRUCTURE-ACTIVITY RELATIONSHIPS[J];;1992-04
5 Department of Physical Chemistry Shen Chuanyong,et al;STUDY ON ANTIOXIDANT ACTIVITIES OF LIGNANS,KADSURENONE AND BURCHLLIN[J];JOURNAL OF BEIJING MEDICAL UNIVERSITY;1995-01
6 Zeng Huawu; Jiang Yuanying; Long Kun; Chen Zhongliang (Department of Pharmacology,College of Pharmacy, Second Military Medical University, Shanghai, 200433);Inhibitory effect of piperbetol,methyl piperbetol,piperol A and piperol B on rabbit platelet aggregation in vitro[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1995-04
7 Zeng Huawu;Jiang Yuanying;Long Kun(Department of Pharmacology,College of Pharmacy, Second Military Medical University,Shanghai,200433);Inhibitory effect of piperol B on Ca~(2+) influx and increase of [Ca~(2+)]_iinduced by PAF in rabbit platelets[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1995-05
8 Zeng Huawu;Jiang Yuanying;Long Kun;Liu Mingzhu(Center of Drug Research, Navy 411Hospital, Teaching Hospital of Second Military Medical University, Shanghai, 200081);Effects of Piperol B on transmembrane metabolism and biosynthesis of PAF in rabbit platelets[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1996-03
9 Guo Ruiyou,Zhang Su ming ,Fang Siyu et al.Department of Neurology,Tongji Hospital,Tongji Medical University,Wuhan 430030;Study on the protective effect of Piper kadsura Ohwi on the focal cerebral ischemia in aged rats.[J];CENTRAL CHINA MEDICAL JOURNAL;2000-04
10 WANG Xue-Song , WANG Wei, RUAN Xu-Zhong Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China;The Study of Piper Kadsura Extract on Brain Protection after Cerebral Ischemia in Rats[J];Chinese Journal of Clinical Neurosciences;2003-01
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Han Guiqiu,et al Research Laboratories of Natural and Biomimetic Drugs;THE STUDIES OF NATURAL PAF ANTAGONISTIC NEOLIGNANS FROM PIPER GENUS AND THEIR STRUCTURE-ACTIVITY RELATIONSHIPS[J];;1992-04
2 Xu Baohua,et alDepartment of Abdominal Surgery Nanjing General Hospital of PLA Nanjig;Effect of Shinanteng extract on treating acute hemorrahgic necrotizing pancreatitis (AHNP)in rast[J];JOURNAL OF DALIAN MEDICAL UNIVERSITY;1997-04
3 Wang Qiuan(School of Chemistry and Chemiscal Engineering,Hunan University,Changsha,Hunan 410082)Liu Jikai(Kunming Institute of Botany,The Chinese Academy of Sciences,Kunming,Yunnan 650204);THE STATUS AND PROGRESS OF MEDICINAL NATURAL PRODUCT CHEMISTRY[J];EXPLORATION OF NATURE;1998-02
4 CHEN Hong-jiang,LI Xiang,CHEN Jian-wei,ZHANG Jie(Pharmacology College of Nanjing University of Chinese Medicine,Nanjing,Jiangsu,210046,China);An Analysis of Chemical Components of Overground Portion of Saururus Chinensis[J];Journal of Nanjing University of Traditional Chinese Medicine;2009-04
5 LI Jun-jie,WANG Xiao-jing,FU Yi-cheng(Institute of Materia Medica,Shandong Academy of Medical Sciences,Jinan 250062,China);Study on Chemical Constituents of Humulus scandens[J];Food and Drug;2008-05
6 HAN Guo-ping, ZHOU Hua-feng (College of Science, Xi'an University of Architecture and Technology, Xi'an 710055, Shaanxi, China);Current pharmacology research advances of lignans[J];Journal of Shaanxi Normal University(Natural Science Edition);2005-S1
7 Wu Qingli,Wang Shengping,Feng Yuxiu,Yang Junshan(Institute of Medicinal Plant Development, Peking Union Medical College andChinese Academy of Medical Sciences,Beijing 100094);CHEMICAL STUDY ON PIPER (PIPERACEAE)[J];Natural Product Research and Development;1998-01
8 Zhang Ke,Ni Wei,Chen Changxiang(Laboratory of Phytochemistry,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650204);THE CONSTITUNETS OF PIPER BOEHMERIAEFOLIUM VAR. TONKINENSE[J];Natural Product Research and Development;1999-01
9 Jian Shuguang 1,Li Ling1,2,Zhang Qianmei1,Lu Qing3,Ye Yushi1,Ren Hai1 1.Guangdong Key Laboratory of Digital Botanical Garden,South China Botanical Garden,Chinese Academy of Sciences,Guangzhou 510650,China; 2.Graduate University of Chinese Academy of Sciences,Beijing 100049,China; 3.Landscape Management Agency of Gaoming District,Foshan Municipality,Foshan 528000,China;Ecological and biological characteristics of Piper hancei[J];Ecology and Environmental Sciences;2009-02
10 ZHENG Jian-rong~1,WANG Qin~2(1.Shaoguan Pharmaceuticals Corporation,Shaoguan Guangdong 512000;2.Guangdong College of Pharmacy,Guangzhou 510224);Researching Survey of Kadsura Heteroclita[J];Journal of Modern Food and Pharmaceuticals;2006-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved