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《Acta Pharmaceutica Sinica》 2008-01
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Biology of thioredoxin and its association with Alzheimer's disease and Parkinson's disease

LI Li-bo,LIU Geng-tao(1.Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)  
Thioredoxin(Trx) is a crucial protein for antioxidative defense,as well as a redox regulator of the intra-and extracellular signaling pathways and transcription factors.In this review,we focus on mammalian Trx and its association with Alzheimer's disease(AD) and Parkinson's disease(PD).Based on the evidence of neuroprotective effects of Trx,up-regulation of Trx may be a good strategy for prevention and treatment of AD and PD.
【Fund】: 国家重点基础研究发展计划973计划课题(2004CB518906).
【CateGory Index】: R749.1;R742.5
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