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《Acta Pharmaceutica Sinica》 2008-01
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JNK/p38 MAPK involves in ginsenoside Rb1 attenuating beta-amyloid peptide(25-35)-induced tau protein hyperphosphorylation in embryo rat cortical neurons

SONG Jin-qiu,CHEN Xiao-chun,ZHANG Jing,HUANG Tianwen,ZENG Yu-qi,SHEN Jie,CHEN Li-min(Fujian Institute of Geriatrics,the Affiliated Union Hospital of Fujian Medical University,Fuzhou 350001,China)  
To explore the effect of ginsenoside Rb1 on JNK/p38 MAPK in the process of β-amyloid peptide(25-35)-induced tau protein hyperphosphorylation,Western blotting and immunocytochemical stain were performed to observe the tau protein phosphorylation and the expression of JNK/p38 MAPK.The level of tau protein phosphorylation in the sites of Ser~(396),Ser~(199/202) and Thr~(205) increased after rat cortical neurons exposed to 20 μmol·L~(-1) Aβ_(25-35),meanwhile the level of JNK/p38 MAPK also increased after Aβ_(25-35) treatment for 12 h.Pretreatment with several doses of ginsenoside Rb1 markedly attenuated tau protein hyperphosphorylation and the expression of JNK/p38 MAPK.Ginsenoside Rb1 markedly attenuated tau protein hyperphosphorylation through JNK/p38 MAPK pathway.
【Fund】: 国家自然科学基金资助项目(30271611);; 福建省科技计划项目(2003F009).
【CateGory Index】: R284
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