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《Acta Pharmaceutica Sinica》 2008-01
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Synthesis and antitumor activity of anthracene-9-carbaldehyde amino-s-triazole Schiff-bases with side-chain of S-acetic acid

HU Guo-qiang~(1),DONG Xiu-li~2,XIE Song-qiang~1,HUANG Wen-long~3(1.Institute of Pharmacy,Henan University,Kaifeng 475001,China;2.The People's Hospital of Queshan,Queshan 463200,China;3.Center of Drug Discovery,China Pharmaceutical University,Nanjing 210009,China)  
To find out a novel lead compound from heterocyclic amine Schiff bases for developing new antitumor agents,each of(4amino-5-substituted-s-triazol-3-ylthio)-acetic acids 2a-j was condensed with anthracene-9-carbaldehyde to obtain Schiff-bases of [4-(anthracen-9-yl methylene) amino]-5-substituted-s-triazol-3-ylsulfanyl]-acetic acids 3a-j.The structures of new compounds synthesized were characterized by elemental analysis and spectral data,and in vitro antitumor activity was also evaluated against CHO,HL60 and L1210 cell lines by MTT assay.
【Fund】: 国家自然科学基金资助项目(30070861);; 河南大学重点科研基金资助项目(04ZDZR009).
【CateGory Index】: R914;R73-3
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