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《ACTA PHARMACEUTICA SINICA》 1999-01
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THERAPEUTIC EFFECTS OF ESCULENTOSIDE A ON PASSIVE HEYMANN NEPHRITIS IN RATS AND ITS INHIBITION ON CYTOKINE PRODUCTION

Ju Dianwen(Ju DW), Zheng Qinyue(Zheng QY) 1, Cao Xuetao(Cao XT), Mei Xiaobin(Mei XB) and Yi Yanghua(Yi YH) 1 (Department of Immunology, 1School of Pharmacy, Second Military Medical University, Shanghai 200433)  
AIM: To investigate the therapeutic effects of esculentoside A, a kind of saponin isolated from the root of the Chinese herb Phytolaca esculenta , on passive Heymann nephritis (PHN) in rats. METHODS: PHN was prepared by injecting Fx1A antibody in rats, and esculentoside A 5, 10 and 20 mg·kg -1 were administered intraperitonealy once a day for 14 consecutive days for the treatment of PHN rats. RESULTS: Esculentoside A 5, 10 and 20 mg·kg -1 decreased urine protein production significantly. Pathological analysis revealed that deposits of IgG along the capillary wall of the glomerulus, glomerulus base membrane thickness and electron dense deposits in PHN rats after treatment with esculentoside A were less than those in control rats. Decreased levels of TNF, IL 1 and IL 6 were observed in the sera of PHN rats following esculentoside A administration. TNF, IL 1 and IL 6 are important cytokines involved in the pathogenesis of inflammatory lesions. CONCLUSION: Esculentoside A possessed potent anti inflammatory effects on PHN. Inhibition of inflammatory cytokine production may partially explain the anti inflammatory effects of esculentoside A.
【Fund】: 国家自然科学基金
【CateGory Index】: R285.5
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