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《ACTA PHARMACEUTICA SINICA》 1999-08
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THE CHEMICAL CONSTITUENTS OF TRIPTERYGIUM WILFORDII

Li Chunyu (Li CY) and Li Yuanchao (Li YC) * (Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031)  
AIM: To study the chemical constituents of the herb Tripterygium wilfordii Hook.F. METHODS: Various column chromatographies with silia gel were employed for the isolation and purification. The structures of compounds were elucidated by spectral analysis. RESULTS: A new kaurane type diterpenoid (1) 16 hydroxy 19,20 epoxy kaurane has been isolated along with four known compounds: tripterfordin (2), (+) medioresinol (3), (-) syringaresinol (4) and nubiletin (5). The structure of (1) was established on the basis of its IR, 1HNMR , 13 CNMR , 1H 1H COSY, HMQC, HMBC, NOESY and MS spectra. CONCLUSION: (1) is a new compound while compounds (3), (5) were isolated from T. Wilfordii for the first time.
【CateGory Index】: R914
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