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《ACTA PHARMACEUTICA SINICA》 1999-08
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STUDIES ON THE STYLE OF INTERACTION OF PIRARUBICIN WITH DNA BY FLUORESCENCE SPECTRA

Hu Min (Hu M), Yang Xin (Yang X), Jin Weijun (Jin WJ), Cao Zhixiang (Cao ZX), Shen Guoli (Shen GL) * and Yu Ruqin (Yu RQ) (Chemistry and Chemical Engineering College, Institute of Chemometrics and Chemical Sensing Technology, Hunan University, C  
AIM: To study the characteristics of the interaction of pirarubicin (THP) with DNA. METHODS: Study and determination of DNA with THP as a fluorescence probe was presented by absorption and fluorescence spectra. RESULTS: The binding constant of the interaction between THP and DNA is 1 66×10 5 L·mol -1 , and the binding site number is about 2 6 base pairs. The limit of detection is 0 91 μg·mL -1 and the linear ranges are 0 91~9 0 μg·mL -1 and 9 0~26 μg·mL -1 respectively for the determination of DNA. CONCLUSION: It indicates that the anthracycline moiety of THP intercalates the stacked base pairs of DNA, which is the major controlling factor. In addition, the complex sugar structure of THP may be bound to the minor groove of DNA double helix.
【Fund】: 高校博士点基金 湖南省科委基金
【CateGory Index】: R914
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