Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
Add to Favorite Get Latest Update


Shen Zancong (Shen ZC), Zhang Qiang (Zhang Q) and Wei Shuli (Wei SL) (School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083)  
AIM: To investigate the hypoglycaemic effect of pulmonary delivered insulin solution (INS SOL) on normal rats. METHODS: INS SOL was administered to the exposed trachea of anesthetized normal rats. Blood samples were collected at specified intervals and blood glucose levels were determined by glucose oxidase method. The hypoglycaemic response was examined after intrapulmonary delivery of INS SOL in three doses (0 5, 1 0 and 5 0 u·kg -1 ) and under two pH conditions (pH 3 and pH 7), as well as co administration of protease inhibitor (bacitracin) or absorption enhancers. The pharmacological bioavailability (PBA), calculated from area above the curve (AAC) was used to evaluate the absorption enhancement of INS SOL from the lung under various conditions. RESULTS: In the absence of additives, a low dose of insulin solution (0 5 u·kg -1 ) produced significant hypoglycaemic effect following intrapulmonary administration, which showed a PBA of 26 0%. The concomitant administration of sodium caprilate, sodium cholate, Brij35, Brij78 as well as bacitracin appeared to be more effective for enhancing the pulmonary absorption of insulin than the other adjuvants like oleic acid, EDTA and 2 hydroxypropyl β cyclodextrin. Absorption of INS SOL under pH 3 condition was significantly increased compared with that under pH 7 condition. CONCLUSION: Pulmonary delivery of INS SOL produced significant hypoglycaemic effect on normal rats, the pulmonary route may be useful for the delivery of insulin.
【CateGory Index】: R965
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 2 Hits
1 Wang Yu-hong,Fang Zhi-yong~1(Hangzhou Aida Pharmaceutical Limited Company,Hangzhou,310016; 1.Zhejiang Hangkang Marine Life Pharmaceutical Limited Company,Hangzhou,310012);Progress of Pulmonary delivery system in home and abroad[J];Shangdong Pharmaceutical Industry;2005-08
2 SHEN Zan Cong, ZHANG Da Wei, ZHANG Qiang 1,ZHOU Tian Yan, WEI Shu Li (Dept of Pharmaceutics,School of Pharmaceutical Sciences,Peking University,Beijing 100083);Hypoglycaemic effect of insulin by buccal delivery in normal rats[J];Chinese Pharmacological Bulletin;2000-06
Chinese Journal Full-text Database 10 Hits
1 CHEN Yang CHEN JinChun(College of Life Science and Technology,Beijing University of Chemical Technology,Beijing 10029,China);Refolding of recombinant human insulin[J];Journal of Beijing University of Chemical Technology(Natural Science Edition);2009-01
2 SHEN Zan Cong #, ZHANG Qiang,WEI Shu Li (# Department of Pharmaceutics,Beijing Medical University,Beijing 100083);Hypoglycemic effects of insulin loaded nanoparticles by pulmonary delivery to normal rats[J];JOURNAL OF BEIJING MEDICAL UNIVERSITY;1999-05
4 YANG Cai Zhe 1,HU Jia Lu 2,XU Liang 2, WU Dao Cheng 3, ZHANG Xue Yong 2 1Department of Endocrinology, Chinese PLA General Airforce Hospital, Beijing 100036,China, 2Institute of Gastroenterology, Xijing Hospital, 3Department of Ch;Hypoglycemic effect of insulin-nanoparticles on diabetic rats[J];Journal of The Fourth Military Medical University;2001-08
5 FU Haiying YAO Side WU Guozhong (Radiation Application Center, Shanghai Institute of Nuclear Research, the Chinese Academy of Sciences, Shanghai 201800);RADIATION INDUCED DEGRADATION OF SODIUM ALGINATE[J];Journal of Radiation Research and Radiation Processing;2003-03
6 PENG Hong, GAO Qiu hua, HUANG Kai xun, XU Hui bi (Institute of Materia Medica, Huazhong University of Science and Technology, Wuhan, Hubei 430074);Preparation of insulin sublingual powder and the determination of insulin in the powder[J];Academic Journal of Guangdong College of Pharmacy;2004-01
7 <author>NG Guanyin SONG Wenxia Yunfu people's hospital in Guangdong 527300, China;<title>udy on the Transdermal Permeability of Insulin in Vitro[J];International Medicine & Health Guidance News;2004-16
8 CHEN Jun 1,YI Yi-mu 2,YANG Xi-xiong 3,WANG Xu-bing 2 1.Department of Pharmacy,Gulou Hospital,Nanjing 210009,China 2 Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China 3 Department of Pharmacy,Second People's H;PRELIMINARY RESEARCH OF INSULIN-LOADED NANOPARTICLES[J];West China Journal of Pharmaceutcal Sciences;2002-04
9 ZHANG Na1,PING Qi-neng2,YAN Ting-ting3, XU Wen-fang1(1.Institute of Pharmaceutics, School of Pharmacy, Shandong University, Jinan 250012, Shandong, China; 2. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, China; 3.Department of Pharmacy, Jinan Central Hospital, Jinan 250013, Shandong, China);Wheat germ agglutinin modifies insulin solid lipid nanoparticles[J];Journal of Shandong University(Health Sciences);2006-02
10 Jiang Xinguo, Xi Niarizhuof Biopharmaceutics, Institute of Pharmaceutical Sciences, Shanghai Medidal University, Shanghai);CONTENTS AND MOLECULAR WEIGHT DETERMINATIONS OF SODIUM ALGINATE PRODUCTS[J];;1990-01
【Secondary References】
Chinese Journal Full-text Database 7 Hits
1 PENG Hong, GAO Qiu hua, HUANG Kai xun, XU Hui bi (Institute of Materia Medica, Huazhong University of Science and Technology, Wuhan, Hubei 430074);Preparation of insulin sublingual powder and the determination of insulin in the powder[J];Academic Journal of Guangdong College of Pharmacy;2004-01
2 PENG Hong1, TIAN Wei-qun, GAO Qiu-hua, HUANG Kai-xun, XU Hui-bi(Institute of Materia Medica, Huazhong University of Science and Technology, Wuhan 430074, China);Study on absorption promoting Azone composite for enhancing the sublingual absorption of insulin[J];Chinese Journal of Biochemical Pharmaceutics;2004-02
3 Huang Tao, Huang Kaixun (Huazhong University of Science and Technology,Wuhan 430073);Research advances in mucosal administration of insulin[J];Tianjin Pharmacy;2004-01
4 ZHANG Yu,LIN Xia,TANG Xing(School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China);Progress on pulmonary delivery devices[J];Journal of Shenyang Pharmaceutical University;2009-10
5 WANG Hui, XU Wei-Ming (Dept of Pharmacology ,Guangdong Medical College, Zhanjiang 524023);Effect of l-menthol pretreated nasal cavity on insulin pharmacological bioavailability[J];Chinese Pharmacological Bulletin;2002-01
6 XU Chen, ZHANG Jun shou (School of Life Sciences, Nanjing University, Nanjing 210093, China);Influence of various absorption enhancers on the hypoglycemic effect of insulin via colon delivery[J];Chinese Pharmacological Bulletin;2004-08
7 WANG Xiang fen 1, YU Hua 2(1. Zhejiang Jinhua CONBA Bio Pharm.CO., LTD., Jinhua 321016, China; 2.Department of Pharmacognosy, China pharmaceutical University, Nanjing 210009, China);The Study of Non-injection Administration System of Insulin[J];Progress In Pharmaceutical Sciences;2002-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved