Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Molecular Diagnostics and Therapy》 2016-03
Add to Favorite Get Latest Update

Association of UCP2 gene rs660339 single nucleotide polymorphism with simple obesity in Chinese Zhuang children adolescents

LI Wugao;LI Zhetao;HUANG Jiwei;YAN Tizhen;LI Jingwen;XU Zehui;TANG Ning;Department of Medical Genetics, Municipal Maternity and Child Healthcare Hospital;  
Objective To investigate the relationship of UCP2 gene rs660339 polymorphisms on obesity in Chinese Zhuang children and adolescents. Methods 285 cases were enrolled in the study,including 151 obese children and adolescents and 134 normal weights as the control. Height and weight of all the participants were collected. Fasting blood-glucose(FBG),total cholesterol(TC),triacylglyceride(TG),high density lipoprotein-cholesterol(HDL-C)and low density lipoprotein-cholesterol(LDL-C)were detected.The genotype of rs660339 were typed by SNa Pshot technique. Statistical analysis of genotype frequencies between obese participants and healthy controls was performed using the SPSS program. Results The metabolic parameters(FBG,TC,TG,HDL-C and VDL-C)of the obese group were significantly different when compared to that of the control group. The C/C,C/T,T/T genotype frequencies of UCP2 rs660339 in simple obese group and normal control group were 40.30%,49.25%,10.45% and 37.09%,50.33%,12.58%,respectively. The C,T allelic frequencies in simple obese group and normal control group were 64.93%,35.07% and 62.25%,37.75%,respectively. Odds ratio(OR)is 1.122(CI:0.797-1.580). The genotype and allelic frequencies of rs660339 in simple obese children were not significantly different from those in controls(P0.05),and there was no significant association between rs660339 and obestity- related traits including FBG,TC,TG,HDL-C and VDL-C. Conclusion rs660339 polymorphism in UCP2 gene is not associated with simple obese in Chinese Zhuang children in Liuzhou,Guangxi province,and there was no significant association among the genotypes and metabolic parameters.
【Fund】: 中国疾病预防控制中心妇幼保健中心合生元母婴营养与健康研究项目(2012FY009);; 广西壮族自治区卫生厅自筹课题(Z2013602)
【CateGory Index】: R723.14
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved