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《Journal of Molecular Diagnostics and Therapy》 2016-03
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Effects of ovulation induction by raloxifene treatment on the expression of COX- 2 and LPAR3 in mouse uterine endometrium during periimplantation period

XIAN Yingjie;CHEN Cairong;ZHOU Xiuqin;YAN Qiuxia;LIANG Xiaoqing;ZHAO Xiaoying;Reproductive Medicine Center, Peoples Hospital of Qingyuan;  
Objective To explore the effect of ovulation induction by raloxifene treatment on endometrial receptivity by detection of the expression of COX-2 and LPAR3 in mouse endometrium during peri-implantation period. Methods 60 female non-pregnant Kunming mice were randomly divided into the RAL treatment group and the normal control group(natural conception). 4.5 days following pregnancy,the expression of COX-2 and LPAR3 in mouse endometrium was detected by immunohistochemical staining.Results There were no significant differences in the expression of COX- 2 and LPAR3 in mouse endometrium between the RAL group and the normal controlled group. Conclusion Raloxifene treatment for ovulation induction does not change the expression of COX- 2 and LPAR3 in mouse endometrium significantly,and has no harmful effects on the endometrial receptivity.
【Fund】: 清远市科技计划项目(2013B015)
【CateGory Index】: R965
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