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《Journal of Molecular Diagnostics and Therapy》 2016-03
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Application of precursor of B- type natriuretic peptide for the diagnosis of viral myocarditis and assessment of heart function in children

LI Zhouwen;Clinical Skills Center Diagnostics Teaching Group,Medical College of Jiaying University;  
Objective To discuss the value of the precursor of B-type natriuretic peptide(NT-proBNP)for assessment of viral myocarditis and heart function in children. Methods The plasma NT-proBNP level was measured by electrochemiluminescence and both of the left ventricular ejection fraction(LVEF) and the left ventricular(LVFS) were assessed by echocardiography in 68 children with viral myocarditis and 109 heathly children. The patients were provided cardiac function grading according to the modified ROSS score. Results There were significant differences among viral myocarditis cases and healthy cases. The level of NT-proBNP in the former(2 870±492 pg/m L)was higher than in the later(156±45 pg/m L).Plasma NT-proBNP level was negatively correlated with the level of LVFS and LVEF,while it was positively correlated with the severity of cardiac function. Conclusion The level of plasma NT-proBNP could reflect the left ventricular dysfunction in viral myocarditis children,and it may be used in diagnosing the viral myocarditis and assessing ventricular dysfunction.
【CateGory Index】: R725.4
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